Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia

Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia Publisher Pubmed

Paragomi P¹ ; Zhang Z² ; Abe SK³ ; Islam MDR^{3, 4} ; Rahman S^{3, 5} ; Saito E⁶ ; Shu XO⁷ ; Dabo B⁸ ; Pham YTH^{1, 2} ; Chen Y^{9, 10} ; Gao YT^{11, 12} ; Koh WP^{13, 14} ; Sawada N¹⁵ ; Malekzadeh R¹⁶ Show All Authors

Paragomi P¹
Zhang Z²
Abe SK³
Islam MDR^{3, 4}
Rahman S^{3, 5}
Saito E⁶
Shu XO⁷
Dabo B⁸
Pham YTH^{1, 2}
Chen Y^{9, 10}
Gao YT^{11, 12}
Koh WP^{13, 14}
Sawada N¹⁵
Malekzadeh R¹⁶
Sakata R¹⁷
Hozawa A¹⁸
Kim J¹⁹
Kanemura S¹⁸
Nagata C²⁰
You SL²¹
Ito H²²
Park SK²³
Yuan JM^{1, 2}
Pan WH^{24, 25}
Wen W⁷
Wang R¹
Cai H¹⁸
Tsugane S¹⁵
Pourshams A¹⁶
Sugawara Y¹⁸
Wada K²⁰
Chen CJ²⁶
Oze I²⁷
Shin A^{23, 28}
Ahsan H²⁹
Boffetta P^{30, 31}
Chia KS³²
Matsuo K^{27, 33}
Qiao YL³⁴
Rothman N³⁵
Zheng W⁷
Inoue M³
Kang D²³
Luu HN^{1, 2}

Show Affiliations

1. Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States
2. Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, PA, United States
3. Division of Prevention, National Cancer Center Institute for Cancer Control, Tokyo, Japan
4. Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
5. Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
6. Institute for Global Health Policy Research, National Center for Global Health and Medicine, Tokyo, Japan
7. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States
8. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, United States
9. Department of Population Health, New York University Grossman School of Medicine, New York, United States
10. Division of Environmental Medicine, New York University Grossman School of Medicine, New York, United States
11. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China
12. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
13. Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
14. Singapore Institute for Clinical Sciences, Agency for Science Technology and Research, Singapore
15. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan
16. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
17. Radiation Effects Research Foundation, Hiroshima, Japan
18. Tohoku University Graduate School of Medicine, Sendai, Japan
19. Graduate School of Science and Policy, National Cancer Center, Gyeonggi-Do, South Korea
20. Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
21. School of Medicine and Big Data Research Center, Fu Jen Catholic University, New Taipei City, Taiwan
22. Division of Cancer Information and Control, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
23. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
24. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
25. Institute of Population Health Sciences, National Health Research Institutes, Miaoli County, Taiwan
26. Genomics Research Center, Academia Sinica, Taipei, Taiwan
27. Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
28. Cancer Research Institute, Seoul National University, Seoul, South Korea
29. Department of Public Health Sciences, The University of Chicago, Chicago, IL, United States
30. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States
31. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
32. Saw Swee Hock School of Public Health, National University of Singapore, Singapore
33. Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
34. Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
35. Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, United States

Source: JAMA Network Open Published:2024

Abstract

IMPORTANCE The global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality. OBJECTIVES To assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population. DESIGN, SETTING, AND PARTICIPANTS This cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium. Cohort enrollment was conducted from January 1, 1984, to December 31, 2002. Median follow-up time was 15.2 years (IQR, 12.1-19.2 years). Data were analyzed from January 15, 2023, through January 15, 2024. EXPOSURE Body mass index, calculated as weight in kilograms divided by height in meters squared. MAIN OUTCOMES AND MEASURES The primary outcomes were CRC incidence and CRC-related mortality. The risk of events is reported as adjusted hazard ratios (AHRs) and 95% CIs for incident CRC and death from CRC using the Cox proportional hazards regression model. RESULTS To assess the risk of incident CRC, 619 981 participants (mean [SD] age, 53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident CRC cases) were included in the study, and to assess CRC-related mortality, 650 195 participants (mean [SD] age, 53.5 [10.2] years; 51.9% female; 4550 identified CRC deaths) were included in the study. A positive association between BMI and risk of CRC was observed among participants with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI, 1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [95% CI, 1.11-1.29]), and greater than 30.0 (AHR, 1.32 [95% CI, 1.19-1.46]) compared with those with a BMI greater than 23.0 to 25.0 (P < .001 for trend), and BMI was associated with a greater increase in risk for colon cancer than for rectal cancer. A similar association between BMI and CRC-related death risk was observed among participants with a BMI greater than 27.5 (BMI >27.5-30.0: AHR, 1.18 [95% CI, 1.04-1.34]; BMI >30.0: AHR, 1.38 [95% CI, 1.18-1.62]; P < .001 for trend) and was present among men with a BMI greater than 30.0 (AHR, 1.87 [95% CI, 1.49-2.34]; P < .001 for trend) but not among women (P = .15 for trend) (P = .02 for heterogeneity). CONCLUSIONS AND RELEVANCE In this cohort study that included a pooled analysis of 17 cohort studies comprising participants across Asia, a positive association between BMI and CRC incidence and related mortality was found. The risk was greater among men and participants with colon cancer. These findings may have implications to better understand the burden of obesity on CRC incidence and related deaths in the Asian population. © 2024 American Medical Association. All rights reserved.

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Style	Citing Format
MLA	Paragomi P, et al.. "Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia." JAMA Network Open, vol. 7, no. 8, 2024, pp. -.
APA	Paragomi P, Zhang Z, Abe SK, Islam MDR, Rahman S, Saito E, Shu XO, Dabo B, Pham YTH, Chen Y, Gao YT, Koh WP, Sawada N, Malekzadeh R, Sakata R, Hozawa A, Kim J, Kanemura S, Nagata C, ... Luu HN (2024). Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia. JAMA Network Open, 7(8), -.
Chicago	Paragomi P, Zhang Z, Abe SK, Islam MDR, Rahman S, Saito E, Shu XO, et al.. "Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia." JAMA Network Open 7, no. 8 (2024): -.
Harvard	Paragomi P et al. (2024) 'Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia', JAMA Network Open, 7(8), pp. -.
Vancouver	Paragomi P, Zhang Z, Abe SK, Islam MDR, Rahman S, Saito E, et al.. Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia. JAMA Network Open. 2024;7(8):-.
BibTex	@article{ author = {Paragomi P and Zhang Z and Abe SK and Islam MDR and Rahman S and Saito E and Shu XO and Dabo B and Pham YTH and Chen Y and Gao YT and Koh WP and Sawada N and Malekzadeh R and Sakata R and Hozawa A and Kim J and Kanemura S and Nagata C and You SL and Ito H and Park SK and Yuan JM and Pan WH and Wen W and Wang R and Cai H and Tsugane S and Pourshams A and Sugawara Y and Wada K and Chen CJ and Oze I and Shin A and Ahsan H and Boffetta P and Chia KS and Matsuo K and Qiao YL and Rothman N and Zheng W and Inoue M and Kang D and Luu HN}, title = {Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia}, journal = {JAMA Network Open}, volume = {7}, number = {8}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Paragomi P AU - Zhang Z AU - Abe SK AU - Islam MDR AU - Rahman S AU - Saito E AU - Shu XO AU - Dabo B AU - Pham YTH AU - Chen Y AU - Gao YT AU - Koh WP AU - Sawada N AU - Malekzadeh R AU - Sakata R AU - Hozawa A AU - Kim J AU - Kanemura S AU - Nagata C AU - You SL AU - Ito H AU - Park SK AU - Yuan JM AU - Pan WH AU - Wen W AU - Wang R AU - Cai H AU - Tsugane S AU - Pourshams A AU - Sugawara Y AU - Wada K AU - Chen CJ AU - Oze I AU - Shin A AU - Ahsan H AU - Boffetta P AU - Chia KS AU - Matsuo K AU - Qiao YL AU - Rothman N AU - Zheng W AU - Inoue M AU - Kang D AU - Luu HN TI - Body Mass Index and Risk of Colorectal Cancer Incidence and Mortality in Asia JO - JAMA Network Open VL - 7 IS - 8 SP - EP - PY - 2024 ER -

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