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Global, Regional, and National Burden of Colorectal Cancer and Its Risk Factors, 1990–2019: A Systematic Analysis for the Global Burden of Disease Study 2019 Publisher Pubmed



Sharma R1 ; Abbasikangevari M2 ; Abdrabu R15 ; Abidi H16 ; Abugharbieh E18 ; Acuna JM21, 22 ; Adhikari S24 ; Advani SM25, 26 ; Afzal MS27 ; Aghaie Meybodi M29 ; Ahinkorah BO30 ; Ahmad S31 ; Ahmadi A3, 32 ; Ahmadi S4 Show All Authors
Authors
  1. Sharma R1
  2. Abbasikangevari M2
  3. Abdrabu R15
  4. Abidi H16
  5. Abugharbieh E18
  6. Acuna JM21, 22
  7. Adhikari S24
  8. Advani SM25, 26
  9. Afzal MS27
  10. Aghaie Meybodi M29
  11. Ahinkorah BO30
  12. Ahmad S31
  13. Ahmadi A3, 32
  14. Ahmadi S4
  15. Ahmed H33
  16. Ahmed LA34
  17. Ahmed MB35, 37
  18. Al Hamad H38, 39
  19. Alahdab F40
  20. Alanezi FM42
  21. Alanzi TM41
  22. Alhalaiqa FAN43, 44
  23. Alimohamadi Y45, 57
  24. Alipour V46, 47
  25. Aljunid SM75, 76
  26. Alkhayyat M77
  27. Almustanyir S79, 80
  28. Alraddadi RM81
  29. Alvand S58
  30. Alvisguzman N84, 85
  31. Amini S86
  32. Ancuceanu R87
  33. Anoushiravani A48
  34. Anoushirvani AA59
  35. Ansarimoghaddam A90
  36. Arabloo J46
  37. Aryannejad A60, 61
  38. Asghari Jafarabadi M92, 98
  39. Athari SS99
  40. Ausloos F101
  41. Ausloos M102, 103
  42. Awedew AF104
  43. Awoke MA105
  44. Ayana TM106
  45. Azadnajafabad S60
  46. Azami H109
  47. Azangoukhyavy M2, 60
  48. Azari Jafari A114
  49. Badiye AD115
  50. Bagherieh S116
  51. Bahadory S120, 122
  52. Baig AA123
  53. Baker JL124
  54. Banach M125, 126
  55. Barrow A127, 128
  56. Berhie AY129
  57. Besharat S130
  58. Bhagat DS132
  59. Bhagavathula AS34, 133
  60. Bhala N134, 135
  61. Bhattacharyya K137, 138
  62. Bhojaraja VS139
  63. Bibi S141
  64. Bijani A142
  65. Biondi A143
  66. Bjorge T146, 147
  67. Bodicha BBA107
  68. Braithwaite D148, 149
  69. Brenner H150
  70. Calina D151
  71. Cao C152
  72. Cao Y153
  73. Carreras G155
  74. Carvalho F156
  75. Cerin E162, 163
  76. Chakinala RC164
  77. Cho WCS165
  78. Chu DT166
  79. Conde J167
  80. Costa VM156
  81. Cruzmartins N157, 168
  82. Dadras O62, 169
  83. Dai X170, 171
  84. Dandona L170, 174, 175
  85. Dandona R170, 171, 174
  86. Danielewicz A176
  87. Demeke FM177
  88. Demissie GD178
  89. Desai R179
  90. Dhamnetiya D180
  91. Dianatinasab M181, 182
  92. Diaz D189, 190
  93. Didehdar M191
  94. Doaei S5, 194
  95. Doan LP197, 198
  96. Dodangeh M49
  97. Eghbalian F110
  98. Ejeta DD199
  99. Ekholuenetale M200, 201
  100. Ekundayo TC203
  101. El Sayed I204
  102. Elhadi M206
  103. Enyew DB207
  104. Eyayu T209
  105. Ezzeddini R121
  106. Fakhradiyev IR210
  107. Farooque U211
  108. Farrokhpour H29, 63, 212
  109. Farzadfar F60
  110. Fatehizadeh A117
  111. Fattahi H217
  112. Fattahi N60, 218
  113. Fereidoonnezhad M221
  114. Fernandes E158
  115. Fetensa G222
  116. Filip I223, 224
  117. Fischer F225
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  119. Gaal PA228, 230
  120. Gad MM78, 231
  121. Gallus S232
  122. Garg T233
  123. Getachew T107
  124. Ghamari SH2, 60
  125. Ghashghaee A234
  126. Ghith N238
  127. Gholamalizadeh M6
  128. Gholizadeh Navashenaq J239
  129. Gizaw AT36
  130. Glasbey JC136
  131. Golechha M240
  132. Goleij P241
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  134. Gorini G154
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  136. Gupta S246
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  138. Gupta VK248
  139. Haddadi R111
  140. Hafezinejad N63, 249
  141. Hajmirzaian A7, 8
  142. Halwani R18, 19
  143. Haque S250
  144. Hariri S59, 118
  145. Hasaballah AI251
  146. Hassanipour S195, 196
  147. Hay SI170, 171
  148. Herteliu C103, 252
  149. Holla R253
  150. Hosseini MS93
  151. Hosseinzadeh M255
  152. Hostiuc M88
  153. Househ M256
  154. Huang J257
  155. Humayun A258
  156. Iavicoli I259
  157. Ilesanmi OS202, 260
  158. Ilic IM262
  159. Ilic MD264
  160. Islami F266
  161. Iwagami M267, 268
  162. Jahani MA142
  163. Jakovljevic M265, 269
  164. Javaheri T270
  165. Jayawardena R272, 273
  166. Jebai R23
  167. Jha RP180, 274
  168. Joo T228
  169. Joseph N275
  170. Joukar F195, 196
  171. Jozwiak JJ276
  172. Kabir A50
  173. Kalhor R235, 236
  174. Kamath A253, 254
  175. Kapoor N115
  176. Karaye IM277
  177. Karimi A63
  178. Kauppila JH278, 279
  179. Kazemi A183
  180. Keykhaei M60, 64
  181. Khader YS280
  182. Khajuria H281
  183. Khalilov R282, 283
  184. Khanali J2, 60
  185. Khayamzadeh M14, 284
  186. Khodadost M285, 286
  187. Kim H287
  188. Kim MS288, 289
  189. Kisa A290, 291
  190. Kisa S292
  191. Kolahi AA2, 9
  192. Koohestani HR293
  193. Kopec JA294, 295
  194. Koteeswaran R296
  195. Koyanagi A297, 298
  196. Krishnamoorthy Y299
  197. Kumar GA174
  198. Kumar M300
  199. Kumar V301
  200. La Vecchia C304
  201. Lami FH305
  202. Landires I306
  203. Ledda C144
  204. Lee SW255
  205. Lee WC309
  206. Lee YY310, 311
  207. Leong E312
  208. Li B313
  209. Lim SS170, 171
  210. Lobo SW314, 315
  211. Loureiro JA159, 316
  212. Lunevicius R317
  213. Madadizadeh F318, 319
  214. Mahmoodpoor A94
  215. Majeed A320
  216. Malekpour MR60
  217. Malekzadeh R59, 184
  218. Malik AA82, 322
  219. Mansourghanaei F195, 196
  220. Mantovani LG323, 324
  221. Martorell M325, 326
  222. Masoudi S59
  223. Mathur P327
  224. Meena JK328
  225. Mehrabi Nasab E65
  226. Mendoza W329
  227. Mentis AFA330
  228. Mestrovic T331, 332
  229. Miao Jonasson J333
  230. Miazgowski B334
  231. Miazgowski T335
  232. Mijena GFW208
  233. Mirmoeeni S114
  234. Mirzaaghazadehattari M95, 337
  235. Mirzaei H338
  236. Misra S339
  237. Mohammad KA340
  238. Mohammadi E66, 216
  239. Mohammadi S100
  240. Mohammadi SM341
  241. Mohammadianhafshejani A32
  242. Mohammed S342, 343
  243. Mohammed TA344
  244. Moka N345, 346
  245. Mokdad AH170, 171
  246. Mokhtari Z119
  247. Molokhia M347
  248. Momtazmanesh S60, 63
  249. Monasta L348
  250. Moradi G219, 220
  251. Moradzadeh R192
  252. Moraga P349
  253. Morgadodacosta J160
  254. Mubarik S350
  255. Mulita F352, 353
  256. Naghavi M170, 171
  257. Naimzada MD354, 355
  258. Nam HS356, 357
  259. Natto ZS83, 302
  260. Nayak BP281
  261. Nazari J193
  262. Nazemalhosseinimojarad E10
  263. Negoi I89, 358
  264. Nguyen CT359
  265. Nguyen SH360
  266. Noor NM361, 363
  267. Noori M51
  268. Noori SMA364
  269. Nunezsamudio V307, 308
  270. Nzoputam CI365
  271. Oancea B366
  272. Odukoya OO367, 368
  273. Oguntade AS261, 362
  274. Okatialiabad H91
  275. Olagunju AT369, 371
  276. Olagunju TO370
  277. Ong S372, 373
  278. Ostroff SM170, 172
  279. Padronmonedero A374
  280. Pakzad R375
  281. Pana A103, 376
  282. Pandey A173
  283. Pashazadeh Kan F56
  284. Patel UK377
  285. Paudel U378, 379
  286. Pereira RB161
  287. Perumalsamy N380, 381
  288. Pestell RG382, 383
  289. Piracha ZZ384
  290. Pollok RCG385
  291. Pourshams A59
  292. Pourtaheri N239
  293. Prashant A386
  294. Rabiee M387
  295. Rabiee N388
  296. Radfar A389
  297. Rafiei S237
  298. Rahman M390
  299. Rahmani AM391
  300. Rahmanian V392
  301. Rajai N303
  302. Rajesh A393
  303. Ramezanidoroh V112
  304. Ramezanzadeh K7
  305. Ranabhat K394, 395
  306. Rashedi S67, 213
  307. Rashidi A60, 396
  308. Rashidi M2
  309. Rashidi MM398
  310. Rastegar M399
  311. Rawaf DL321, 401
  312. Rawaf S320, 402
  313. Rawassizadeh R271
  314. Razeghinia MS403, 405
  315. Renzaho AMN406, 407
  316. Rezaei N60, 408
  317. Rezaei N60, 408
  318. Rezaei S52, 409
  319. Rezaeian M396
  320. Rezazadehkhadem S60
  321. Roshandel G130
  322. Saberayad MM18, 410
  323. Saberzadehardestani B411
  324. Saddik B20
  325. Sadeghi H11, 131
  326. Saeed U412, 413
  327. Sahebazzamani M397, 404
  328. Sahebkar A414, 415
  329. Salek Farrokhi A416
  330. Salimi A2, 214
  331. Salimzadeh H59
  332. Samadi P113
  333. Samaei M417
  334. Samy AM418
  335. Sanabria J244, 419
  336. Santricmilicevic MM262, 263
  337. Saqib MAN28, 420
  338. Sarveazad A53
  339. Sathian B38, 421
  340. Satpathy M422, 423
  341. Schneider IJC424
  342. Sekerija M425, 426
  343. Sepanlou SG59, 184
  344. Seylani A427
  345. Sha F428
  346. Shafiee SM185
  347. Shaghaghi Z429
  348. Shahabi S186
  349. Shaker E66, 213
  350. Sharifian M430
  351. Sharifirad J12
  352. Sheikhbahaei S249
  353. Shetty JK140
  354. Shirkoohi R70, 71
  355. Shobeiri P66, 215
  356. Siddappa Malleshappa SK431
  357. Silva DAS432
  358. Silva Julian G433
  359. Singh AD77
  360. Singh JA434, 435
  361. Siraj MS436
  362. Sivandzadeh GR187, 188
  363. Skryabin VY437
  364. Skryabina AA438
  365. Socea B89, 439
  366. Solmi M440
  367. Soltanizangbar MS96
  368. Song S441
  369. Szerencses V228
  370. Szocska M229
  371. Tabaresseisdedos R442, 443
  372. Tabibian E72
  373. Taheri M13, 54
  374. Taheri Abkenar Y12
  375. Taherkhani A113
  376. Talaat IM18, 205
  377. Tan KK444
  378. Tbakhi A445
  379. Tesfaye B446
  380. Tiyuri A55, 400
  381. Tollosa DN447
  382. Touvier M448, 449
  383. Tran BX450
  384. Tusa BS451
  385. Ullah I452, 453
  386. Ullah S141
  387. Vacante M143
  388. Valadan Tahbaz S454, 455
  389. Veroux M145
  390. Vo B457
  391. Vos T170, 171
  392. Wang C458
  393. Westerman R459
  394. Woldemariam M108
  395. Yahyazadeh Jabbari SH454
  396. Yang L460, 461
  397. Yazdanpanah F73, 97
  398. Yu C350
  399. Yuce D462
  400. Yunusa I463
  401. Zadnik V464
  402. Zahir M74, 456
  403. Zare I465
  404. Zhang ZJ351
  405. Zoladi M17

Source: The Lancet Gastroenterology and Hepatology Published:2022


Abstract

Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990–2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408–868 574) to 2·17 million (2·00–2·34), and deaths increased from 518 126 (493 682–537 877) to 1·09 million (1·02–1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3–23·0) per 100 000 to 26·7 (24·6–28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5–14·9) per 100 000 to 13·7 (12·6–14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7–320·7) per 100 000 to 295·5 (275·2–313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9–80·0] per 100 000), Monaco (60·7 [48·5–73·6] per 100 000), and Andorra (56·6 [42·8–71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0–37·1] per 100 000), Brunei (30·3 [26·6–34·1] per 100 000), and Hungary (28·6 [23·6–34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age <50 years), particularly in high Socio-demographic Index (SDI) countries. Globally, a diet low in milk (15·6%), smoking (13·3%), a diet low in calcium (12·9%), and alcohol use (9·9%) were the main contributors to colorectal cancer DALYs in 2019. Interpretation: The increase in incidence rates in people younger than 50 years requires vigilance from researchers, clinicians, and policy makers and a possible reconsideration of screening guidelines. The fast-rising burden in low SDI and middle SDI countries in Asia and Africa calls for colorectal cancer prevention approaches, greater awareness, and cost-effective screening and therapeutic options in these regions. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
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