Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Bismuth Oxide Nanoparticles As Agents of Radiation Dose Enhancement in Intraoperative Radiotherapy Publisher Pubmed



Alyani Nezhad Z1 ; Geraily G1, 2 ; Hataminia F3 ; Parwaie W4 ; Ghanbari H3 ; Gholami S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Physics and Medical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Physics, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran

Source: Medical Physics Published:2021


Abstract

Purpose: Intraoperative radiotherapy (IORT) technique is an advanced radio therapeutic method used for delivery of a single high-dose radiation during surgery while removing healthy tissues from the radiation field. Nowadays, growing attention is being paid to IORT for its low-energy (kilovoltage) delivery as it requires less radiation protection, but suffers several disadvantages, including high-dose delivery and prolonged treatment time. The application of nanoparticles with high atomic number and high attenuation coefficients in kilovoltage energy may help overcome the mentioned shortcomings. This study was designed to investigate and quantify the mean dose enhancement factor (DEF) in the presence of nanoparticles using IORT method. Methods: Bismuth oxide nanoparticles (Bi2O3NPs), both in sheet and spherical formats, were synthesized using a novel hydrothermal method and characterized with x-ray diffraction (XRD), transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) analysis. Genipin-gelatin gel dosimeter (GENIPIN) was produced in three batches of pure with sheet and with spherical nanoparticles in concentration of 46.596 µg/ml, and irradiated with 50 kV x-rays. Results: Samples were scanned by a spectrophotometer, which indicated a DEF of 3.28 (Formula presented.) 0.37 and 2.50 (Formula presented.) 0.23 for sheet and spherical NPs, respectively. According to the results of this study, GENIPIN is a suitable dosimeter for the evaluation of three-dimensional dose distribution in the presence Bi2O3 NPs. Conclusion: As a result, IORT along with Bi2O3 NPs has the potential to reduce treatment time and/or normal tissue dose; moreover, it could provide localized dose enhancement. © 2021 American Association of Physicists in Medicine
Related Docs
View other Related Docs
1. Investigation of the Dose Enhancement Effect of Spherical Bismuth Oxide Nanoparticles in External Beam Radiotherapy, Nanomedicine Research Journal (2020)
2. Evaluation of Dose Enhancement Effect of Bismuth Oxide Nanoparticles by Means of Magat and Npag Gel Dosimeters, Journal of Radioanalytical and Nuclear Chemistry (2022)
3. High-Performance Spirulina-Bismuth Biohybrids for Enhanced Computed Tomography Imaging, ACS Sustainable Chemistry and Engineering (2020)
4. A Review Study on Application of Gel Dosimeters in Low Energy Radiation Dosimetry, Applied Radiation and Isotopes (2022)
5. The Effect of Bismuth Nanoparticles in Kilovoltage and Megavoltage Radiation Therapy Using Magnetic Resonance Imaging Polymer Gel Dosimetry, Radiation Physics and Chemistry (2020)
6. Dosimetry and Radioenhancement Comparison of Gold Nanoparticles in Kilovoltage and Megavoltage Radiotherapy Using Magat Polymer Gel Dosimeter, Journal of Biomedical Physics and Engineering (2019)
7. Investigation of Isotropic Radiation of Low Energy X-Ray Intra-Operative Radiotherapy by Magat Gel Dosimeter, Radiation Physics and Chemistry (2021)
8. Monte Carlo Simulation and Analytical Calculation Methods to Investigate the Potential of Nanoparticles for Intrabeam® Iort Machine, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
Experts (# of related papers)
View all Related Experts
Ghazaleh Geraily (7)
Mehdi Khoobi (2)
Other Related Docs
9. The Role of Bismuth Nanoparticles in the Inhibition of Bacterial Infection, World Journal of Microbiology and Biotechnology (2023)
10. Toxicity, Morphological and Structural Properties of Chitosan-Coated Bi2o3-Bi(Oh)3 Nanoparticles Prepared Via Dc Arc Discharge in Liquid: A Potential Nanoparticle-Based Ct Contrast Agent, Micro and Nano Letters (2019)
11. Synthesis and Characterization of Bismuth Oxide Nanoparticle by Thermal Decomposition of Bismuth-Based Mof and Evaluation of Its Nanocomposite, Iranian Journal of Chemistry and Chemical Engineering (2021)
12. Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology, Nano Biomedicine and Engineering (2016)
13. Engineering and Quantification of Bismuth Nanoparticles As Targeted Contrast Agent for Computed Tomography Imaging in Cellular and Animal Models, Journal of Drug Delivery Science and Technology (2021)
14. Determination of the Dose Enhancement Exclusively in Tumor Tissue Due to the Presence of Gnps, Applied Radiation and Isotopes (2019)
15. Radiation Dose Escalation by Injecting Bismuth, Gold and Platinum Nanoparticles Into a Tumour During High Dose Rate 192Ir Brachytherapy: A Monte Carlo Study, Radiation and Environmental Biophysics (2025)
16. Accelerated Partial Breast Irradiation: A New Strategy for Early-Stage Breast Cancer, Archives of Breast Cancer (2019)
17. The Impact of Nano-Sized Gold Particles on the Target Dose Enhancement Based on Photon Beams Using by Monte Carlo Method, Nanomedicine Research Journal (2016)