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Natural Killer Cells in Covid-19: From Infection, to Vaccination and Therapy Publisher



Zafarani A1 ; Razizadeh MH2 ; Pashangzadeh S3, 4 ; Amirzargar MR1 ; Taghavifarahabadi M5 ; Mahmoudi M6
Authors
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Authors Affiliations
  1. 1. Department of Hematology & Blood Banking, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Immunology Today, Universal Scientific Education & Research Network (USERN), Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran

Source: Future Virology Published:2023


Abstract

Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed. © 2023 Future Medicine Ltd.
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