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Covid-19 Immunotherapy: Treatment Based on the Immune Cell-Mediated Approaches Publisher Pubmed



Zavvar M1 ; Yahyapoor A2 ; Baghdadi H3 ; Zargaran S2 ; Assadiasl S4 ; Abdolmohammadi K5 ; Hossein Abooei A1 ; Reza Sattarian M2 ; Jalalifarahani M1 ; Zarei N1 ; Farahvash A6 ; Fatahi Y7, 8 ; Deniz G9 ; Zarebavani M1 Show All Authors
Authors
  1. Zavvar M1
  2. Yahyapoor A2
  3. Baghdadi H3
  4. Zargaran S2
  5. Assadiasl S4
  6. Abdolmohammadi K5
  7. Hossein Abooei A1
  8. Reza Sattarian M2
  9. Jalalifarahani M1
  10. Zarei N1
  11. Farahvash A6
  12. Fatahi Y7, 8
  13. Deniz G9
  14. Zarebavani M1
  15. Nicknam MH4, 10

Source: International Immunopharmacology Published:2022


Abstract

Multiple efforts are currently underway to control and treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19) worldwide. Despite all efforts, the virus that emerged in Wuhan city has rapidly spread globally and led to a public health emergency of international concern (PHEIC) due to the lack of approved antiviral therapy. Nevertheless, SARS-CoV-2 has had a significant influence on the evolution of cellular therapeutic approaches. Adoptive immune cell therapy is innovative and offers either promising prophylactic or therapy for patients with moderate-to-severe COVID-19. This approach is aimed at developing safety and providing secure and effective therapy in combination with standard therapy for all COVID-19 infected individuals. Based on the effective results of previous studies on both inflammatory and autoimmune diseases, various immune cell therapies against COVID-19 have been reviewed and discussed. It must be considered that the application of cell therapy for treatment and to eliminate infected respiratory cells could result in excessive inflammation, so this treatment must be used in combination with other treatments, despite its many beneficial efforts. © 2022 Elsevier B.V.
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