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Preventive Effects of Garlic (Allium Sativum) on Oxidative Stress and Histopathology of Cardiac Tissue in Streptozotocin-Induced Diabetic Rats Publisher Pubmed



Naderi R1 ; Mohaddes G1 ; Mohammadi M1 ; Alihemmati A2 ; Badalzadeh R1 ; Ghaznavi R3 ; Ghyasi R1 ; Mohammadi SH4
Authors
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Authors Affiliations
  1. 1. Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Histology and Embryology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Acta Physiologica Hungarica Published:2015


Abstract

Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects of garlic (Allium sativum) were investigated in the blood and heart of streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats were randomly divided into four groups: control, garlic, diabetic, and diabetic+garlic. Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (50 mg/kg) in male rats. Rats were fed with raw fresh garlic homogenate (250 mg/kg) six days a week by gavage for a period of 6 weeks. At the end of the 6th week blood samples and heart tissues were collected and used for determination of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and histological evaluation. Induction of diabetes increased MDA levels in blood and homogenates of heart. In diabetic rats treated with garlic, MDA levels decreased in blood and heart homogenates. Treatment of diabetic rats with garlic increased SOD, GPX and CAT in blood and heart homogenates. Histopathological finding of the myocardial tissue confirmed a protective role for garlic in diabetic rats. Thus, the present study reveals that garlic may effectively modulate antioxidants status in the blood and heart of streptozotocin induced-diabetic rats. © 2015 Akademiai Kiado, Budapest.
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