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Immunopathogenesis of Viral Infections in Neurological Autoimmune Disease Publisher Pubmed



Habibi MA1, 2 ; Nezhad Shamohammadi F3 ; Rajaei T4 ; Namdari H5 ; Pashaei MR6 ; Farajifard H2 ; Ahmadpour S7
Authors
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Authors Affiliations
  1. 1. Multiple Sclerosis Research Center, Neuroscience Institut, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Cell and Gene Therapy Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  5. 5. Iranian Tissue Bank and Research Center, Imam Khomeini Hospital, Tehran University of Medical Science, Tehran, Iran
  6. 6. Department of Internal Medicine, School of Medicine, Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Science, Urmia, Iran
  7. 7. Patient Safety Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran

Source: BMC Neurology Published:2023


Abstract

Autoimmune diseases develop due to self-tolerance failure in recognizing self and non-self-antigens. Several factors play a role in inducing autoimmunity, including genetic and environmental elements. Several studies demonstrated the causative role of viruses; however, some studies showed the preventive effect of viruses in the development of autoimmunity. Neurological autoimmune diseases are classified based on the targets of autoantibodies, which target intracellular or extracellular antigens rather than neurons. Several theories have been hypothesized to explain the role of viruses in the pathogenesis of neuroinflammation and autoimmune diseases. This study reviewed the current data on the immunopathogenesis of viruses in autoimmunity of the nervous system. © 2023, The Author(s).
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