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The Effect of Resveratrol Supplementation on C-Reactive Protein (Crp) in Type 2 Diabetic Patients: Results From a Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Hosseini H1 ; Koushki M1 ; Khodabandehloo H2 ; Fathi M2 ; Panahi G1 ; Teimouri M1 ; Majidi Z1 ; Meshkani R1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Complementary Therapies in Medicine Published:2020


Abstract

Objective: C-reactive protein (CRP) is considered to be an inflammatory marker in type 2 diabetes (T2D) and it is produced by liver cells. The evidence has suggested that resveratrol has anti-inflammatory effect. This study aimed to evaluate the effect of resveratrol supplementation on CRP level in patients with T2D using a systematic review and meta-analysis of randomized controlled trials. Methods: Electronic databases were completely searched using Medline, ISI Web of Science, EMBASE and Cochrane Library and Scopus until October 2019. Meta-analysis was performed using random-effects model and inverse variance method. Heterogeneity and publication bias were evaluated in selected studies. Sensitivity analyses and prespecified subgroup were conducted to evaluate potential heterogeneity. Meta-regression was performed to assess the effect of potential confounders on the estimated effect sizes. Results: Six trials comprising a total of 491 subjects were included in this meta-analysis. The results showed significant reduction in the level of CRP [SMD (-0.34 mg/l) (95 % CI, -0.52, to -0.16) p < 0.05] in participants with T2D following supplementation with resveratrol. No significant publication bias was observed in the meta-analysis. Subgroup and sensitivity analyses indicated that the pooled effects of resveratrol supplementation on CRP level in T2D patients were affected by resveratrol dose and duration of resveratrol. Random-effects meta-regression did not indicate any significant association of CRP level with potential confounders including resveratrol dose, duration of treatment, age and gender of type 2 diabetic patients. Conclusion: We found a significant reduction in CRP level in patients with type 2 diabetes, who received resveratrol supplementation. © 2019 Elsevier Ltd
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