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Aptamer Hybrid Nanocomplexes As Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review Publisher Pubmed



Ahmadi S2, 3 ; Arab Z1 ; Safarkhani M1 ; Nasseri B4, 5 ; Rabiee M6 ; Tahriri M7 ; Webster TJ8 ; Tayebi L7 ; Rabiee N1
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  2. 2. Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Chemical Engineering Department and Bioengineering Division, Hacettepe University, Beytepe, 06800, Ankara, Turkey
  5. 5. Chemical Engineering and Applied Chemistry Department, Atilim University, Ankara, Turkey
  6. 6. Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  7. 7. Marquette University School of Dentistry, Milwaukee, 53233, WI, United States
  8. 8. Department of Chemical Engineering, Northeastern University, Boston, 02115, MA, United States

Source: International Journal of Nanomedicine Published:2020


Abstract

With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs. © 2020 Rabiee et al.
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