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Aptamer-Decorated Nanocarriers for Viral Adsorption: A Special Look at Covid-19 Publisher



Handali S1 ; Rezaei M2, 3
Authors
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Authors Affiliations
  1. 1. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Institute for Natural Products and Medicinal Plants (INPMP), Tarbiat Modares University, Tehran, Iran

Source: Molecular Therapy Nucleic Acids Published:2024


Abstract

Viral infections are one of the leading causes of death in the world. One main challenge in fighting against these diseases is the unavailability of effective eradicating drugs and specific treatments. Nanocarriers and aptamer-decorated nanocarriers are designed to attach to many targets, including viral particles. By lowering the viral infectivity and attachment capability, they add therapeutic values even without containing antiviral drugs. Nevertheless, the nanoparticles (NPs) with encapsulated antiviral drugs can display extra therapeutic effects. Furthermore, it has been shown that aptamers can bind to viral particles and nanocarriers, presenting promising approaches for the identification of viruses and treatment of viral infections. Although there is no satisfying literature revealing the strong therapeutic potential of nanotechnology against COVID-19, the following information can provide new perspectives for upcoming investigations pertaining to developing effective aptamer-nanocarrier agents against COVID-19. © 2024 The Authors
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