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Mesenchymal Stem Cell-Based Therapy As a New Therapeutic Approach for Acute Inflammation Publisher Pubmed



Abdolmohammadi K1 ; Mahmoudi T2 ; Alimohammadi M3 ; Tahmasebi S3 ; Zavvar M5 ; Hashemi SM3, 4
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran
  2. 2. 17 Shahrivar Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Medical Nanothechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Life Sciences Published:2023


Abstract

Acute inflammatory diseases such as acute colitis, kidney injury, liver failure, lung injury, myocardial infarction, pancreatitis, septic shock, and spinal cord injury are significant causes of death worldwide. Despite advances in the understanding of its pathophysiology, there are many restrictions in the treatment of these diseases, and new therapeutic approaches are required. Mesenchymal stem cell-based therapy due to immunomodulatory and regenerative properties is a promising candidate for acute inflammatory disease management. Based on preclinical results, mesenchymal stem cells and their-derived secretome improved immunological and clinical parameters. Furthermore, many clinical trials of acute kidney, liver, lung, myocardial, and spinal cord injury have yielded promising results. In this review, we try to provide a comprehensive view of mesenchymal stem cell-based therapy in acute inflammatory diseases as a new treatment approach. © 2022 Elsevier Inc.
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