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The Critical Role of Mesenchymal Stromal/Stem Cell Therapy in Covid-19 Patients: An Updated Review Publisher Pubmed



Ebrahimi M1 ; Rad MTS2 ; Zebardast A3 ; Ayyasi M4 ; Goodarzi G5, 6 ; Tehrani SS5, 6
Authors
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Authors Affiliations
  1. 1. Neonatal and Child Health Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Psychiatric and Behavioral Sciences Research Center, Addiction Research Institute, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Critical Care Nursing, Islamic Azad University, Sari Branch, Sari, Iran
  5. 5. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell Biochemistry and Function Published:2021


Abstract

New coronavirus disease 2019 (COVID-19), as a pandemic disaster, has drawn the attention of researchers in various fields to discover suitable therapeutic approaches for the management of COVID-19 patients. Currently, there are many worries about the rapid spread of COVID-19; there is no approved treatment for this infectious disease, despite many efforts to develop therapeutic procedures for COVID-19. Emerging evidence shows that mesenchymal stromal/stem cell (MSC) therapy can be a suitable option for the management of COVID-19. These cells have many biological features (including the potential of differentiation, high safety and effectiveness, secretion of trophic factors and immunoregulatory features) that make them suitable for the treatment of various diseases. However, some studies have questioned the positive role of MSC therapy in the treatment of COVID-19. Accordingly, in this paper, we will focus on the therapeutic impacts of MSCs and their critical role in cytokine storm of COVID-19 patients. © 2021 John Wiley & Sons Ltd.
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