Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer

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Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer Publisher Pubmed

Roostaee M¹ ; Derakhshani A² ; Mirhosseini H³ ; Banaee Mofakham E⁴ ; Fathikarkan S^{5, 6} ; Mirinejad S⁷ ; Sargazi S^{7, 8} ; Barani M⁹

Source: Nanoscale Published:2023

Abstract

Nanoniosome-based drug codelivery systems have become popular therapeutic instruments, demonstrating tremendous promise in cancer therapy, infection treatment, and other therapeutic domains. An emerging form of vesicular nanocarriers, niosomes are self-assembling vesicles composed of nonionic surfactants, along with cholesterol or other amphiphilic molecules. This comprehensive review focuses on how nanosystems may aid in making anticancer and antibacterial pharmaceuticals more stable and soluble. As malleable nanodelivery instruments, the composition, types, preparation procedures, and variables affecting the structure and stability of niosomes are extensively investigated. In addition, the advantages of dual niosomes for combination therapy and the administration of multiple medications simultaneously are highlighted. Along with categorizing niosomal drug delivery systems, a comprehensive analysis of various preparation techniques, including thin-layer injection, ether injection, and microfluidization, is provided. Dual niosomes for cancer treatment are discussed in detail regarding the codelivery of two medications and the codelivery of a drug with organic, plant-based bioactive compounds or gene agents. In addition, niogelosomes and metallic niosomal carriers for targeted distribution are discussed. The review also investigates the simultaneous delivery of bioactive substances and gene agents, including siRNA, microRNA, shRNA, lncRNA, and DNA. Additional sections discuss the use of dual niosomes for cutaneous drug delivery and treating leishmanial infections, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The study concludes by delineating the challenges and potential routes for nanoniosome-based pharmaceutical codelivery systems, which will be useful for nanomedicine practitioners and researchers. © 2024 The Royal Society of Chemistry.

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Style	Citing Format
MLA	Roostaee M, et al.. "Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer." Nanoscale, vol. 16, no. 6, 2023, pp. 2713-2746.
APA	Roostaee M, Derakhshani A, Mirhosseini H, Banaee Mofakham E, Fathikarkan S, Mirinejad S, Sargazi S, Barani M (2023). Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer. Nanoscale, 16(6), 2713-2746.
Chicago	Roostaee M, Derakhshani A, Mirhosseini H, Banaee Mofakham E, Fathikarkan S, Mirinejad S, Sargazi S, Barani M. "Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer." Nanoscale 16, no. 6 (2023): 2713-2746.
Harvard	Roostaee M et al. (2023) 'Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer', Nanoscale, 16(6), pp. 2713-2746.
Vancouver	Roostaee M, Derakhshani A, Mirhosseini H, Banaee Mofakham E, Fathikarkan S, Mirinejad S, et al.. Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer. Nanoscale. 2023;16(6):2713-2746.
BibTex	@article{ author = {Roostaee M and Derakhshani A and Mirhosseini H and Banaee Mofakham E and Fathikarkan S and Mirinejad S and Sargazi S and Barani M}, title = {Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer}, journal = {Nanoscale}, volume = {16}, number = {6}, pages = {2713-2746}, year = {2023} }
RIS	TY - JOUR AU - Roostaee M AU - Derakhshani A AU - Mirhosseini H AU - Banaee Mofakham E AU - Fathikarkan S AU - Mirinejad S AU - Sargazi S AU - Barani M TI - Composition, Preparation Methods, and Applications of Nanoniosomes As Codelivery Systems: A Review of Emerging Therapies With Emphasis on Cancer JO - Nanoscale VL - 16 IS - 6 SP - 2713 EP - 2746 PY - 2023 ER -

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