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An Overview of Allergic Bronchopulmonary Aspergillosis; Diagnostic and Therapeutic Aspects



Afsarian MH1 ; Moradi F2 ; Kouhpayeh SA3 ; Ataollahi MR1 ; Farzanehpoor A4 ; Fakhim H5 ; Khodavaisy S6 ; Badali H7
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  2. 2. Faculty of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Pharmacology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  4. 4. Enghelab Health Center, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Antimicrobial Resistance Research Center, Department of Medical Mycology and Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Journal of Mazandaran University of Medical Sciences Published:2016

Abstract

Allergic Bronchopulmonary Aspergillosis (ABPA) is a hypersensitivity response to Aspergillus antigens in patients with asthma or cystic fibrosis (CF). The inhalation of spores from the environment is followed by growth of hyphae in the mucus of the bronchial tree and stimulates an immune response involving Th2 CD4+ T cells and IgE and IgG antibodies. Although diagnostic procedure for ABPA is a big challenge, serological marker (measurement of IgE antibody) for the diagnosis of ABPA is chosen in clinical. However, cross-reactivity may also occur between crude fungal extracts. Therefore, combination of clinical, biological and radiological criteria with molecular-based allergy can solve this problem. Although, the mainstay of treatment for ABPA is corticosteroids followed by antifungal regimes, but treatment is dependent on the ABPA stage with asthma control, prevention and treatment of acute disease, and preventing the progression of bronchiectasis. The current review paper presents a comprehensive overview of the allergic bronchopulmonary aspergillosis based on diagnostic and therapeutic aspects. © 2016, Mazandaran University of Medical Sciences. Engineering. All rights reserved.
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