Correlation Between the Serum Procalcitonin Level and the Extension and Severity of Coronary Artery Disease in Patients With Non-St-Segment Elevation Myocardial Infarction Publisher



Hashemipour SV¹ ; Pourhosseini H¹ ; Hosseinsabet A¹ Show Affiliations
Source: Cardiovascular Endocrinology and Metabolism Published:2019

Abstract

Objectives Research has shown correlations between some, but not all, inflammatory mediators and coronary atherosclerosis burden. Conflicting results have been reported on the correlation between the serum procalcitonin (PCT) level and the severity and extension of coronary artery disease (CAD). We evaluated the correlation between PCT and the severity and extension of CAD in patients with non-ST-elevation myocardial infarction (NSTEMI). Patients and methods In this prospective cross-sectional study, the serum PCT level was measured 48 h after hospital admission in 131 patients with a diagnosis of NSTEMI. All the patients underwent selective coronary angiography, and the severity and extension of their CAD was evaluated with the Gensini score. The study population was assigned to two groups on the basis of the median of the Gensini score: those with a score higher than the median and those with a score lower than the median. Results There was no statistically significant difference with regard to the serum PCT level between the two groups (P = 0.511). In the multivariable logistic regression analysis, after adjustment for the potential confounders, the serum PCT level was not a determinant of the Gensini score (P = 0.502). Conclusion The second 24-h postadmission serum PCT level was not correlated with the severity and extension of CAD according to the Gensini score in our patients with NSTEMI. © 2019 Wolters Kluwer Health, Inc.