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Association of Programmed Cell Death 1 and Programmed Cell Death 1 Ligand Gene Polymorphisms With Delayed Graft Function and Acute Rejection in Kidney Allograft Recipients Pubmed



Zolfaghari L1 ; Solgi G2 ; Nafar M3 ; Ahmadpour P3 ; Lassanpezeshki M4 ; Amirzargar MA5 ; Sharbafi MH1 ; Pourrezagholi F3 ; Samadian F3 ; Parvin M3 ; Razeghi E6 ; Nicknam MH1 ; Ghodssighasemabadi R1 ; Amirzargar A1
Authors
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Immunology Department, School of Medicine, Hamadan University of Medical sciences, Hamadan, Iran
  3. 3. Chronic Kidney Disease Research Center, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Nephrology Research Center, Imam Khomeini Hospital, Tehran University of medical sciences, Tehran, Iran
  5. 5. Department of Urology, School of Medicine, Hamadan University of Medical sciences, Hamadan, Iran
  6. 6. Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Kidney Diseases Published:2015


Abstract

Introduction. The genetic variations of co-stimulatory molecules can affect the extent of T cell activity during T-cell mediated immunity, especially in transplant patients. This study aimed to investigate the association of programmed cell death 1 (PDCD1) and programmed cell death 1 ligand 1 (PDCD1LG1) gene polymorphisms with clinical outcome of kidney transplantation. Materials and Methods. A total of 122 patients with a kidney transplant were included in this retrospective study. Patients were classified into two groups of biopsy-proven acute allograft rejection (AAR) and stable graft function (SGF) during the 5-year followup period. Four single nucleotide polymorphisms in PDCD1 and PDCD1LG1 were determined in the groups of patients as well as in 208 healthy control individuals. Results. The frequencies of PD-1.3 (+7146 G > A), PD-1.9 (+7625 C > T), PD-L1 (8923 A > C), and PD-L1 (+6777 C > G) genotypes and alleles were not significantly different between the AAR and SGF groups. In comparison with healthy controls, PD-1.9 (+7625 C > T) genotype and T allele were significantly more frequent in all of the patients and in those with SGF. Overall, 27 of 122 kidney allograft recipients experienced delayed graft function, and a higher frequency of PD-1.9 (+7625 C > T) genotype and T allele was observed in this group versus those without delayed graft function. Similarly, a significant high frequency of this genotype was found among the AAR subgroup of patients with delayed graft function. Conclusions. Our results indicate that potentially functional genetic variation in PDCD1 can influence the outcome of kidney transplantation. © 2015, Iranian Society of Nephrology. All rights reserved.
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