Effects of Diode and Erbium Lasers As an Adjunct to Scaling and Root Planing on Clinical and Immunological Parameters in Non-Surgical Periodontal Treatment: A Split-Mouth Randomized Controlled Clinical Trial—“Effects of Lasers on Immunological Parameters” Publisher Pubmed



Sayar F¹ ; Hashemi S² ; Chiniforush N^{3, 4} ; Seyed Jafari E⁵ ; Jandaghi A² Show Affiliations
Source: Lasers in Medical Science Published:2022

Abstract

This study evaluated the effects of diode and erbium lasers, as an adjunct to scaling and root planing (SRP), on clinical and immunological parameters in non-surgical periodontal therapy. In this split-mouth randomized controlled clinical trial, 17 participants with at least one periodontally involved tooth in each quadrant received oral hygiene instruction and full-mouth SRP. At baseline, probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), and full-mouth plaque index (FMPI) were measured, and gingival crevicular fluid (GCF) sampling was performed. Next, one random quadrant in each participant received 940 nm diode laser (1 W, continuous-wave), and another quadrant received 2780 nm Er,Cr:YSGG laser (1.5 W, 30 Hz) irradiation. The GCF levels of interleukin (IL)-10 and matrix metalloproteinase (MMP)-13 were measured at baseline, and after 2 and 6 months using ELISA. The clinical parameters were also measured. Data were analyzed by repeated measures ANOVA. Significant clinical improvement was noted in all groups (P < 0.05). CAL in the control group was higher at 6 months than 2 months. The increase in IL-10 in erbium group was significantly greater than that in other groups (P < 0.001). The MMP-13 level was significantly lower in laser groups with greater reduction in erbium group (P < 0.001). Application of 940 nm diode and 2780 nm Er,Cr:YSGG lasers as an adjunct to SRP significantly decreased the GCF level of MMP-13, with no significant clinical advantage over SRP monotherapy. Application of 2780 nm Er,Cr:YSGG laser in addition to SRP increased the GCF level of IL-10. Trial registration numbers: IRCT20140318017053N11 and IRCT20140318017053N9. © 2022, The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.