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The Expression Patterns of Malat-1, Neat-1, Thril, and Mir-155-5P in the Acute to the Post-Acute Phase of Covid-19 Disease Publisher Pubmed



Abbasikolli M1 ; Sadri Nahand J2 ; Kiani SJ3 ; Khanaliha K4 ; Khatami A3 ; Taghizadieh M5 ; Torkamani AR6 ; Babakhaniyan K7 ; Bokharaeisalim F3
Authors
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Authors Affiliations
  1. 1. Iran University of Medical Sciences, Deputy of Health, Tehran, Iran
  2. 2. Tabriz University of Medical Sciences, Infectious and Tropical Diseases Research Center, Tabriz, Iran
  3. 3. Iran University of Medical Sciences, School of Medicine, Department of Virology, Tehran, Iran
  4. 4. University of Medical Sciences, Institute of Immunology and Infectious Diseases, Research Center of Pediatric Infectious Diseases, Tehran, Iran
  5. 5. Tabriz University of Medical Sciences, Center for Women's Health Research Zahra, School of Medicine, Department of Pathology, Tabriz, Iran
  6. 6. Tehran University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry, Tehran, Iran
  7. 7. Iran University of Medical Sciences, School of Nursing and Midwifery, Department of Medical Surgical Nursing, Tehran, Iran

Source: Brazilian Journal of Infectious Diseases Published:2022


Abstract

Introduction: One of the hallmarks of COVID-19 is overwhelming inflammation, which plays a very important role in the pathogenesis of COVID-19. Thus, identification of inflammatory factors that interact with the SARS-CoV-2 can be very important to control and diagnose the severity of COVID-19. The aim of this study was to investigate the expression patterns of inflammation-related non-coding RNAs (ncRNAs) including MALAT-1, NEAT-1, THRIL, and miR-155-5p from the acute phase to the recovery phase of COVID-19. Methods: Total RNA was extracted from Peripheral Blood Mononuclear Cell (PBMC) samples of 20 patients with acute COVID-19 infection and 20 healthy individuals and the expression levels of MALAT-1, NEAT-1, THRIL, and miR-155-5p were evaluated by real-time PCR assay. Besides, in order to monitor the expression pattern of selected ncRNAs from the acute phase to the recovery phase of COVID-19 disease, the levels of ncRNAs were re-measured 6‒7 weeks after the acute phase. Result: The mean expression levels of MALAT-1, THRIL, and miR-155-5p were significantly increased in the acute phase of COVID-19 compared with a healthy control group. In addition, the expression levels of MALAT-1 and THRIL in the post-acute phase of COVID-19 were significantly lower than in the acute phase of COVID-19. According to the ROC curve analysis, these ncRNAs could be considered useful biomarkers for COVID-19 diagnosis and for discriminating between acute and post-acute phase of COVID-19. Discussion: Inflammation-related ncRNAs (MALAT-1, THRIL, and miR-150-5p) can act as hopeful biomarkers for the monitoring and diagnosis of COVID-19 disease. © 2022 Sociedade Brasileira de Infectologia
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