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Expression Analysis of Nf-Κb-Associated Long Noncoding Rnas in Peripheral Blood Mononuclear Cells From Relapsing-Remitting Multiple Sclerosis Patients Publisher Pubmed



Soltanmoradi S1 ; Tavakolpour V1, 2 ; Moghadasi AN3 ; Kouhkan F1
Authors

Source: Journal of Neuroimmunology Published:2021


Abstract

Long noncoding RNAs (lncRNAs) as potential disease biomarkers might be related to severe course of multiple sclerosis (MS). We evaluated expression levels of NF-κB-associated lncRNAs including HOTAIR, THRIL, H19, NKILA, and ANRIL; as well as expression of IL-6, TNF-α and MMP9, in peripheral blood mononuclear cells (PBMCs) from 60 relapse-remitting MS (RRMS) patients. At relapse phase of RRMS, up-regulation of ANRIL and H19 was positively correlated with the overexpression of IL-6; high levels of THRIL and HOTAIR was positively correlated with increased levels of TNF-α and MMP9, respectively; however, the NKILA expression was negatively correlated with the expression of TNF-α. © 2021 Elsevier B.V.
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