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Global Mortality From Dementia: Application of a Newmethod and Results From the Global Burden of Disease Study 2019 Publisher



Nichols E1 ; Abdallah F2 ; Abdoli A3 ; Abosetugn AE4 ; Abrha WA5 ; Abualhasan A2 ; Abugharbieh E6 ; Akinyemi RO7, 8 ; Alahdab F9 ; Alanezi FM10 ; Alipour V11, 12 ; Ansari I13 ; Arabloo J11 ; Ashrafganjouei A14 Show All Authors
Authors
  1. Nichols E1
  2. Abdallah F2
  3. Abdoli A3
  4. Abosetugn AE4
  5. Abrha WA5
  6. Abualhasan A2
  7. Abugharbieh E6
  8. Akinyemi RO7, 8
  9. Alahdab F9
  10. Alanezi FM10
  11. Alipour V11, 12
  12. Ansari I13
  13. Arabloo J11
  14. Ashrafganjouei A14
  15. Avan A15
  16. Ayano G16
  17. Babar ZUD17
  18. Baig AA18
  19. Banach M19, 20
  20. Barboza MA21, 22
  21. Barkercollo SL23
  22. Baune BT24, 25
  23. Srikanth Bhagavathula A26, 27
  24. Bhattacharyya K28, 29
  25. Bijani A30
  26. Biondi A31
  27. Birhan TA32
  28. Biswas A33
  29. Bolla SR34
  30. Boloor A35
  31. Brayne C36
  32. Brenner H37
  33. Burkart K1, 38
  34. Burns RA39
  35. Nagaraja SB40
  36. Carvalho F41
  37. Castrodearaujo LFS42
  38. Catalalopez F43, 44
  39. Cerin E45, 46
  40. Cernigliaro A244
  41. Cherbuin N39
  42. Jasmine Choi JY47
  43. Chu DT48
  44. Dagnew B49
  45. Dai X1
  46. Dandona L1, 50, 51
  47. Dandona R1, 38, 50
  48. Diaz D52, 53
  49. Dibaji Forooshani ZS54
  50. Douiri A55
  51. Duncan BB56
  52. Edvardsson D57, 58
  53. Eljaafary SI2
  54. Eskandari K59, 60
  55. Eskandarieh S61
  56. Feigin VL1, 62, 63
  57. Fereshtehnejad SM64, 65
  58. Fernandes E66
  59. Ferrara P67
  60. Filip I68, 69
  61. Fischer F70
  62. Gaidhane S71
  63. Gebregzabiher KZ5
  64. Ghashghaee A11, 72
  65. Gholamian A73, 74
  66. Gnedovskaya EV75
  67. Golechha M76
  68. Gupta R77, 78
  69. Hachinski V79, 80
  70. Hamidi S81
  71. Hankey GJ82, 83
  72. Haro JM84, 85
  73. Hassan A2
  74. Hay SI138
  75. Heidari G86
  76. Heidarisoureshjani R87
  77. Househ M88
  78. Hussain R89
  79. Hwang BF90
  80. Ilic IM91
  81. Ilic MD92
  82. Naghibi Irvani SS93
  83. Iso H94
  84. Iwagami M95, 96
  85. Jha RP97, 98
  86. Kalani R99
  87. Kandel H100, 101
  88. Karch A102
  89. Kasa AS103
  90. Kengne AP104, 105
  91. Kim YE106
  92. Kim YJ107
  93. Kisa S108
  94. Kisa A109, 110
  95. Kivimaki M111, 112
  96. Komaki H113, 114
  97. Kukull WA117
  98. Kumar GA50
  99. Kumar M118, 119
  100. Landires I120, 121
  101. Leonardi M122
  102. Lim SS138
  103. Liu X123
  104. Logroscino G124, 125
  105. Lopez AD1, 38, 126
  106. Lorkowski S127, 128
  107. Loy CT129, 130
  108. Amin HIM131, 132
  109. Manafi N133, 134
  110. Manjunatha N135
  111. Mehndiratta MM136, 137
  112. Menezes RG138
  113. Meretoja A139, 140
  114. Merkin A62
  115. Metekiya WM141
  116. Misganaw AT38, 142
  117. Mohajer B143
  118. Ibrahim NM144
  119. Mohammad Y145
  120. Mohapatra A146
  121. Mohebi F143, 147
  122. Mokdad AH1, 38
  123. Mondello S148
  124. Mossie TB149
  125. Mulugeta A150, 151
  126. Nagel G152
  127. Naveed M153
  128. Nayak VC154
  129. Kandel SN155
  130. Nguyen SH156
  131. Nguyen HLT157
  132. Nunezsamudio V121, 158
  133. Ogbo FA159
  134. Olagunju AT160, 161
  135. Orru H162, 163
  136. Ostojic SM164
  137. Ostroff SM1, 165
  138. Otstavnov N166
  139. Otstavnov SS166, 167
  140. Owolabi MO168, 169
  141. Pathak M170
  142. Toroudi HP171, 172
  143. Peterson CB173
  144. Pham HQ157
  145. Phillips MR174, 175
  146. Piradov MA63
  147. Pottoo FH176
  148. Prada SI177, 178
  149. Angga Pribadi DR179
  150. Radfar A180
  151. Raggi A122
  152. Rahim F181, 182
  153. Ram P183
  154. Rana J184, 185
  155. Rashedi V186
  156. Rawaf S187, 188
  157. Rawaf DL189, 190
  158. Reinig N1
  159. Rezaei N191, 192
  160. Robinson SR193
  161. Romoli M194, 195
  162. Sachdev PS196, 197
  163. Sahathevan R140, 198
  164. Sahebkar A199, 200
  165. Sahraian MA61
  166. Sattin D122
  167. Saylan M201
  168. Sayyah M202
  169. Schiavolin S122
  170. Schmidt MI56
  171. Shahid I203
  172. Shaikh MA204
  173. Shigematsu M205
  174. Shin JI206
  175. Shiri R207
  176. Siddiqi TJ208
  177. Silva JP41
  178. Singh JA209, 210
  179. Soheili A211
  180. Spurlock EE1
  181. Szoeke CEI212, 213
  182. Tabaresseisdedos R214, 215
  183. Taddele BW216
  184. Thakur B217, 218
  185. Thekke Purakkal AS219
  186. Tovanipalone MR220, 221
  187. Tran BX222
  188. Travillian RS1
  189. Tripathi M223
  190. Tsegaye GW224
  191. Usman MS225
  192. Vacante M31
  193. Velazquez DZ53
  194. Venketasubramanian N226, 227
  195. Vidale S228, 229
  196. Vlassov V230
  197. Wang YP231
  198. Wei J232
  199. Weiss J233
  200. Weldemariam AH5
  201. Wimo A234
  202. Wu C235, 236
  203. Yadollahpour A237
  204. Yamagishi K238, 239
  205. Yeshitila YG240
  206. Yonemoto N241, 242
  207. Zadey S236
  208. Zhang ZJ243
  209. Murray CJL138
  210. Vos T1, 38

Source: Alzheimer's and Dementia: Translational Research and Clinical Interventions Published:2021


Abstract

Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally. © 2021 The Authors.
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