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Correlations Between Covid-19 and Burden of Dementia: An Ecological Study and Review of Literature Publisher Pubmed



Azarpazhooh MR1, 2, 3, 4 ; Amiri A4 ; Morovatdar N5 ; Steinwender S6 ; Rezaei Ardani A7 ; Yassi N8, 9 ; Biller J10 ; Stranges S3, 11, 19 ; Tokazebani Belasi M12 ; Neya SK12 ; Khorram B13 ; Sheikh Andalibi MS14 ; Arsangjang S15 ; Mokhber N16 Show All Authors
Authors
  1. Azarpazhooh MR1, 2, 3, 4
  2. Amiri A4
  3. Morovatdar N5
  4. Steinwender S6
  5. Rezaei Ardani A7
  6. Yassi N8, 9
  7. Biller J10
  8. Stranges S3, 11, 19
  9. Tokazebani Belasi M12
  10. Neya SK12
  11. Khorram B13
  12. Sheikh Andalibi MS14
  13. Arsangjang S15
  14. Mokhber N16
  15. Di Napoli M17, 18
Show Affiliations
Authors Affiliations
  1. 1. Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, ON, Canada
  2. 2. Department of Clinical Neurological Sciences, Western University, London, ON, Canada
  3. 3. Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada
  4. 4. Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Clinical Research Development Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Health Information Science, PhD (candidate) Western University, London, ON, Canada
  7. 7. Psychiatry and Behavioural Sciences Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. Departments of Medicine and Neurology, Melbourne Brain Centre at The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia
  9. 9. Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
  10. 10. Department of Neurology, Loyola University Chicago Stritch School of Medicine, Maywood, IL, United States
  11. 11. Department of Family Medicine Schulich School of Medicine, Dentistry Western University, London, ON, Canada
  12. 12. Research Centre for Prevention of cardiovascular disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran
  13. 13. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
  14. 14. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  15. 15. Department of Biostatistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  16. 16. Department of Psychiatry, St Joseph's Health Care London, Western University, Canada
  17. 17. Department of Neurology and Stroke Unit, San Camillo de’ Lellis General District Hospital, Rieti, Italy
  18. 18. Neurological Section, Neuro-epidemiology Unit, SMDN-Centre for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L'Aquila, Italy
  19. 19. Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg

Source: Journal of the Neurological Sciences Published:2020


Abstract

Introduction: Current evidence on the association between COVID-19 and dementia is sparse. This study aims to investigate the associations between COVID-19 caseload and the burden of dementia. Methods: We gathered data regarding burden of dementia (disability-adjusted life years [DALYs] per 100,000), life expectancy, and healthy life expectancy (HALE) from the Global Burden of Disease (GBD) 2017 study. We obtained COVID-19 data from Our World in Data database. We analyzed the association of COVID-19 cases and deaths with the burden of dementia using Spearman's rank correlation coefficient. Results: Globally, we found significant positive (p <.001) correlations between life expectancy (r = 0.60), HALE (r = 0.58), and dementia DALYs (r = 0.46) with COVID-19 caseloads. Likewise, we found similar correlations between life expectancy (r = 0.60), HALE (r = 0.58) and dementia DALYs (r = 0.54) with COVID-19 mortality. Conclusion: Health policymakers should clarify a targeted model of disease surveillance in order to reduce the dual burden of dementia and COVID-19. © 2020
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