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Effects of Exercise Training Together With Tamoxifen in Reducing Mammary Tumor Burden in Mice: Possible Underlying Pathway of Mir-21 Publisher Pubmed



Khori V1 ; Amani Shalamzari S2 ; Isanejad A3, 4 ; Alizadeh AM2 ; Alizadeh S5 ; Khodayari S2 ; Khodayari H6 ; Shahbazi S7 ; Zahedi A2 ; Sohanaki H8 ; Khaniki M9 ; Mahdian R10 ; Saffari M11 ; Fayad R12
Authors
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Authors Affiliations
  1. 1. Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Cancer Research Center, Tehran University of Medical Sciences, Tehran, 1419733141, Iran
  3. 3. Immunological Response Research Center, Shahed University, Tehran, Iran
  4. 4. Physical Education Department, Shahed University, Tehran, Iran
  5. 5. Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Cancer Models Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Medical Genetics Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  8. 8. Physiology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Pathology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran
  11. 11. Medical Genetics Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Colon Cancer Center, South Carolina University, United States

Source: European Journal of Pharmacology Published:2015


Abstract

Exercise training has an anti-tumor effect and can reduce tumor growth; however, the exact underlying mechanisms of its protective effects are still obscure. MicroRNA (miR)-21 is a predictor in cancer survival, and has a potential use as an indicator of therapeutic outcome in breast malignancies. Forty-eight female BALB/c mice were equally divided into six groups to investigate the effects of interval exercise training with tamoxifen on miR-21 expression and its possible assumed mechanisms in an estrogen receptor-positive breast cancer model. ELISA, immunohistochemistry, western blot, qRT-PCR assays were performed at the end of the study. Tumor size was significantly declined in exercise training and tamoxifen groups compared to tumor group (P<0.05). Expression of miR-21 was significantly down-regulated in trained and tamoxifen treated mice in comparison with tumor group (P<0.05). Exercise training was as effective as tamoxifen treatment in decreasing serum estradiol and ER-α expression (P<0.05). Exercise training and tamoxifen reduced tumor IL-6 levels, NF-kB and STAT3 expressions, and up-regulated TPM1 and PDCD4 expressions (P<0.05). Both exercise and tamoxifen had synergistic effects in reducing miR-21 and Bcl-2, and up-regulating PDCD4 expression. Results showed that interval exercise training may reduce mammary tumor burden in mice through possible underlying pathway of miR-21. © 2015 Elsevier B.V. All rights reserved.
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