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Serum Calcitonin Gene-Related Peptide and Inflammatory Marker Dynamics Across the Migraine Attack Cycle: A Case-Control Analysis Publisher

Summary: Do migraine biomarkers change during attacks? A study recruited 169 people to compare CGRP and inflammatory markers; the abstract reports design, not results. #Migraine #Biomarkers

Togha M ; Ghorbani Z ; Jafari E ; Salami Z ; Rafiee P ; Shoaibinobarian N K ; Moghadas F
Authors

Source: Current Journal of Neurology Published:2025


Abstract

Background: The role of calcitonin gene-related peptide (CGRP) and inflammatory pathways in migraine pathophysiology remains to be fully elucidated. This study addressed inconsistencies in the existing literature by comparing serum levels of CGRP and inflammatory markers in patients with migraine during (ictal) and between (interictal) attacks, relative to healthy controls. Methods: A total of 169 individuals were enrolled: 39 patients with chronic migraine (CM), 100 with episodic migraine (EM), and 30 healthy controls matched for age and sex. Among patients with EM, 63 were assessed during a migraine attack, while 37 were assessed during an interictal phase. Copyright © 2025 Iranian Neurological Association, and Tehran University of Medical Sciences.
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