Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study

Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study Publisher Pubmed

Movahedi M¹ ; Jamee M^{2, 3} ; Ghaffaripour H¹ ; Noori F¹ ; Ghaini M⁴ ; Eskandarzadeh S⁴ ; Enayat J¹ ; Eslamian G⁴ ; Pourdowlat G⁵ ; Sharifinejad N⁶ ; Poorabdollah M¹ ; Nadji SA¹ ; Fallahi M¹ ; Daneshmandi Z¹ Show All Authors

Movahedi M¹
Jamee M^{2, 3}
Ghaffaripour H¹
Noori F¹
Ghaini M⁴
Eskandarzadeh S⁴
Enayat J¹
Eslamian G⁴
Pourdowlat G⁵
Sharifinejad N⁶
Poorabdollah M¹
Nadji SA¹
Fallahi M¹
Daneshmandi Z¹
Heshmatnia J⁵
Eslaminejad A⁵
Fakharian A⁵
Vasheghani M⁵
Moniri A⁷
Mirenayat MS⁵
Tabarsi P⁷
Marjani M⁷
Rezaei N^{8, 9, 10}
Seppanen MRJ¹¹
Mansouri D^{1, 7}
Mahdaviani SA¹
Velayati AA¹

Show Affiliations

1. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Pediatric Infections Research Center, Research Institute for Childrenâ€™s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Pediatric Nephrology Research Center, Research Institute for Childrenâ€™s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Allergy and Clinical Immunology, Mofid Childrenâ€™s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
7. Clinical Tuberculosis and Epidemiology Research Centre, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Research Center for Immunodeficiencies, Childrenâ€™s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
9. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
10. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
11. Rare Disease and Pediatric Research Centers, Hospital for Children and Adolescents and Adult Immunodeficiency Unit, Inflammation Center, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland

Source: Allergologia et Immunopathologia Published:2022

Abstract

Background: Inborn errors of immunity (IEIs) are a group of congenital diseases caused by genetic defects in the development and function of the immune system. The involvement of the respiratory tract is one of the most common presentations in IEIs. Methods: Overall, 117 patients with diagnosed IEIs were followed-up within 8 years at the National Research Institute of Tuberculosis and Lung Diseases (NRITLD). Demographic, clinical, and laboratory data were collected in a questionnaire. Pulmonary function test (PFT), chest X-ray (CXR), and high-resolution computed tomography (HRCT) scans were obtained where applicable. Results: Our study population consisted of 48 (41%) patients with predominantly antibody deficiencies (PADs), 39 (32%) patients with congenital defects of phagocytes, 14 (11.9%) patients with combined immunodeficiency (CID), and 16 (14%) patients with Mendelian susceptibility to mycobacterial diseases (MSMD). Recurrent pneumonia was the most common manifestation, while productive cough appeared to be the most common symptom in almost all diseases. PFT showed an obstructive pattern in patients with PAD, a restrictive pattern in patients with CID, and a mixed pattern in patients with CGD. HRCT findings were consistent with bronchiectasis in most PAD patients, whereas consolidation and mediastinal lesions were more common in the other groups. Conclusions: Pulmonary manifestations vary among different groups of IEIs. The screening for lung complications should be performed regularly to reveal respiratory pathologies in early stages and follow-up on already existing abnormalities. © 2022. Codon Publications. Published by Codon Publications.

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Style	Citing Format
MLA	Movahedi M, et al.. "Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study." Allergologia et Immunopathologia, vol. 50, no. 1, 2022, pp. 80-84.
APA	Movahedi M, Jamee M, Ghaffaripour H, Noori F, Ghaini M, Eskandarzadeh S, Enayat J, Eslamian G, Pourdowlat G, Sharifinejad N, Poorabdollah M, Nadji SA, Fallahi M, Daneshmandi Z, Heshmatnia J, Eslaminejad A, Fakharian A, Vasheghani M, Moniri A, ... Velayati AA (2022). Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study. Allergologia et Immunopathologia, 50(1), 80-84.
Chicago	Movahedi M, Jamee M, Ghaffaripour H, Noori F, Ghaini M, Eskandarzadeh S, Enayat J, et al.. "Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study." Allergologia et Immunopathologia 50, no. 1 (2022): 80-84.
Harvard	Movahedi M et al. (2022) 'Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study', Allergologia et Immunopathologia, 50(1), pp. 80-84.
Vancouver	Movahedi M, Jamee M, Ghaffaripour H, Noori F, Ghaini M, Eskandarzadeh S, et al.. Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study. Allergologia et Immunopathologia. 2022;50(1):80-84.
BibTex	@article{ author = {Movahedi M and Jamee M and Ghaffaripour H and Noori F and Ghaini M and Eskandarzadeh S and Enayat J and Eslamian G and Pourdowlat G and Sharifinejad N and Poorabdollah M and Nadji SA and Fallahi M and Daneshmandi Z and Heshmatnia J and Eslaminejad A and Fakharian A and Vasheghani M and Moniri A and Mirenayat MS and Tabarsi P and Marjani M and Rezaei N and Seppanen MRJ and Mansouri D and Mahdaviani SA and Velayati AA}, title = {Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study}, journal = {Allergologia et Immunopathologia}, volume = {50}, number = {1}, pages = {80-84}, year = {2022} }
RIS	TY - JOUR AU - Movahedi M AU - Jamee M AU - Ghaffaripour H AU - Noori F AU - Ghaini M AU - Eskandarzadeh S AU - Enayat J AU - Eslamian G AU - Pourdowlat G AU - Sharifinejad N AU - Poorabdollah M AU - Nadji SA AU - Fallahi M AU - Daneshmandi Z AU - Heshmatnia J AU - Eslaminejad A AU - Fakharian A AU - Vasheghani M AU - Moniri A AU - Mirenayat MS AU - Tabarsi P AU - Marjani M AU - Rezaei N AU - Seppanen MRJ AU - Mansouri D AU - Mahdaviani SA AU - Velayati AA TI - Pulmonary Manifestations in a Cohort of Patients With Inborn Errors of Immunity: An 8-Year Follow-Up Study JO - Allergologia et Immunopathologia VL - 50 IS - 1 SP - 80 EP - 84 PY - 2022 ER -

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