Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Covid-19 Infection Risk Following Elective Arthroplasty and Surgical Complications in Covid-19-Vaccinated Patients: A Multicenter Comparative Cohort Study Publisher



Mirghaderi SP1, 2 ; Salimi M1 ; Moharrami A1 ; Hosseinidolama R1, 2 ; Mirghaderi SR1 ; Ghaderi M3 ; Motififard M4 ; Mortazavi SMJ1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Orthopedic Surgery, Kashani University Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Arthroplasty Today Published:2022


Abstract

Background: We aimed to determine symptomatic Coronavirus disease 2019 (COVID-19) rates within 1 month of elective arthroplasty for vaccinated individuals and to determine whether vaccination guarantees protection against COVID-19 after arthroplasty (primary outcome). In addition, the 90-day surgical complications were compared to those of an unvaccinated group (secondary outcome). Methods: A prospective cohort study was conducted on elective joint arthroplasty patients at 3 tertiary hospitals in 2 major cities (Tehran and Isfahan) in our country (Iran). The outcomes of the COVID-19-vaccinated group were assessed between October 2021 and March 2022. Ninety-day surgical complications were compared with a historical cohort of unvaccinated patients treated earlier in the pandemic (April 2020-March 2021). Results: The study included 1717 consecutive patients: 962 vaccinated and 755 unvaccinated. In the vaccinated group, 38 patients (3.9%) contracted COVID-19, 4 (10.5%) were hospitalized again, and none required intensive care unit admission. The multivariate logistic regression analysis revealed that COVID-19-positive cases are more likely to be female (odds ratio [OR] = 12.5), to have visitors to their home (OR = 4.7), and to stay longer in the hospital (OR = 1.2) than COVID-19-negative cases. Compared to unvaccinated patients, the postoperative COVID-19 rate was not significantly different (3.9% vs 2.4%, P = .07). The incidence of surgical complications was similar between the 2 groups (P > .05). Conclusions: The vaccination does not provide a guarantee that a patient will not contract COVID-19 following their arthroplasty surgery, especially in a region with a high rate of COVID-19. We believe reasonable perioperative COVID-19 precautions may be warranted even in vaccinated patients. © 2022 The Authors
Related Docs
View other Related Docs
1. Covid-19 Infection Rate After Urgent Versus Elective Total Hip Replacement Among Unvaccinated Individuals: A Multicenter Prospective Cohort Amid the Covid-19 Pandemic, Annals of Medicine and Surgery (2022)
2. Comparison of Low-Dose (162 Mg) and High-Dose (650 Mg) Aspirin Prophylaxis Following Total Joint Arthroplasty: A Prospective Cohort Study, Annals of Medicine and Surgery (2023)
3. Incidence of Symptomatic Covid-19 in Unvaccinated Patients Within One Month After Elective Total Joint Arthroplasty: A Multicenter Study, Arthroplasty Today (2022)
4. Predictors of Core Decompression Success in Patients With Femoral Head Avascular Necrosis, Archives of Bone and Joint Surgery (2023)
5. Recent Developments in Sars-Cov-2 Vaccines: A Systematic Review of the Current Studies, Reviews in Medical Virology (2023)
6. Acute Ischemic Stroke and Vaccine-Induced Immune Thrombotic Thrombocytopenia Post Covid-19 Vaccination; a Systematic Review, Journal of the Neurological Sciences (2022)
7. Safety and Immunogenicity of a Recombinant Receptor-Binding Domain-Based Protein Subunit Vaccine (Noora Vaccine™) Against Covid-19 in Adults: A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial, Journal of Medical Virology (2023)
8. Low-Versus High-Dose Aspirin for Venous Thromboembolic Prophylaxis After Total Joint Arthroplasty: A Systematic Review and Meta-Analysis, Journal of Orthopaedic Surgery and Research (2024)
Experts (# of related papers)
View all Related Experts
Seyed Ahmad Seyed Alinaghi (22)
Nima Rezaei (10)
Other Related Docs
9. Covid-19 Vaccines Cost-Effectiveness Analysis: A Scenario for Iran, Vaccines (2022)
10. Diagnostic Performance of a Novel Antigen-Capture Elisa for the Detection of Sars-Cov-2, Analytical Biochemistry (2023)
11. Vlp-Based Covid-19 Vaccines: An Adaptable Technology Against the Threat of New Variants, Vaccines (2021)
12. Association of Sars-Cov-2 Vaccination or Infection With Bell Palsy: A Systematic Review and Meta-Analysis, JAMA Otolaryngology - Head and Neck Surgery (2023)
13. Short-Term Sars-Cov-2 Re-Infection Rate in Vaccinated Health Workers Based on Received Vaccines: A Cross-Sectional Study, Current Respiratory Medicine Reviews (2023)
14. Molecular Variants of Sars-Cov-2: Antigenic Properties and Current Vaccine Efficacy, Medical Microbiology and Immunology (2022)
15. Artificial Intelligence in Covid-19 Management: A Systematic Review, Journal of Computer Science (2023)
16. Covid-19 Vaccine Boosters: The Good, the Bad, and the Ugly, Vaccines (2021)
17. Sars-Cov-2: Current Trends in Emerging Variants, Pathogenesis, Immune Responses, Potential Therapeutic, and Vaccine Development Strategies, International Immunopharmacology (2021)
18. Importance of Pre-Operative Covid-19 Screening Test in Elective Surgeries, Iranian Journal of Microbiology (2022)
19. Response to the Letter to the Editor: “Covid-19 Infection Risk, Elective Arthroplasty and Surgical Complications, and Covid-19 Vaccination: Correspondence”, Arthroplasty Today (2023)
20. Sars-Cov-2-Related and Covid-19 Vaccine-Induced Thromboembolic Events: A Comparative Review, Reviews in Medical Virology (2022)
21. Sars-Cov-2 Antibody Response After Bbibp-Corv (Sinopharm) Vaccination in Cancer Patients: A Case-Control Study, Frontiers in Medicine (2023)
22. The Effectiveness of Covid-19 Vaccines in Reducing the Incidence, Hospitalization, and Mortality From Covid-19: A Systematic Review and Meta-Analysis, Frontiers in Public Health (2022)
23. Estimating the Size of the Hidden Population of Covid-19, Infectious Disorders - Drug Targets (2024)
24. Incidence of Bell's Palsy After Coronavirus Disease (Covid-19) Vaccination: A Systematic Review and Meta-Analysis; [Incidencia De La Paralisis De Bell Despues De La Vacunacion Contra La Covid-19: Una Revision Sistematica Y Un Metanalisis], Neurologia (2024)
25. Simultaneous Femoral Head Reduction Osteotomy (Fhro) Combined With Periacetabular Osteotomy (Pao) for the Treatment of Severe Femoral Head Asphericity in Perthes Disease, Journal of Orthopaedic Surgery and Research (2022)
26. Covid-19 Vaccines Mix-And-Match: The Concept, the Efficacy and the Doubts, Journal of Medical Virology (2022)
27. Short-Term Safety of Covaxin, Sinopharm, Sputnik V, and Astrazeneca Covid-19 Vaccines Among Iranian Healthcare Workers: A Cross-Sectional Study, Archives of Clinical Infectious Diseases (2024)
28. The Quest for a Better Fight: How Can Nanomaterials Address the Current Therapeutic and Diagnostic Obstacles in the Fight Against Covid-19?, Journal of Drug Delivery Science and Technology (2022)
29. Covid-19 Mortality in Patients With Immunodeficiency and Its Predictors: A Systematic Review, European Journal of Medical Research (2022)
30. Effectiveness of Covid-19 Vaccines Against Delta (B.1.617.2) Variant: A Systematic Review and Meta-Analysis of Clinical Studies, Vaccines (2022)
31. The Chimera of S1 and N Proteins of Sars-Cov-2: Can It Be a Potential Vaccine Candidate for Covid-19?, Expert Review of Vaccines (2022)
32. Safety and Efficacy of Rcp Recombinant Spike Protein Covid-19 Vaccine Compared to Sinopharm Bbibp: A Phase Iii, Non-Inferiority Trial, Heliyon (2024)
33. Total Hip Arthroplasty Via Direct Anterior Approach for Osteonecrosis; Comparison With Primary Hip Osteoarthritis in a Mid Term Follow Up, Journal of Clinical Orthopaedics and Trauma (2022)
34. Seroconversion Following the First, Second, and Third Dose of Sars-Cov-2 Vaccines in Immunocompromised Population: A Systematic Review and Meta-Analysis, Virology Journal (2022)
35. The Psychological, Philosophical, and Political Implications of Covid-19, Infectious Disorders - Drug Targets (2023)
36. Covid-19 Vaccinations: The Unknowns, Challenges, and Hopes, Journal of Medical Virology (2022)
37. Challenges Posed by Covid-19 in Cancer Patients: A Narrative Review, Cancer Medicine (2022)
38. Side Effects and Short-Term Safety of Covid-19 Vaccines for Pregnant Women: A Case Study of Southeast Iran, Archives of Clinical Infectious Diseases (2023)
39. The Impacts of Covid-19 Pandemic on Service Delivery and Treatment Outcomes in People Living With Hiv: A Systematic Review, AIDS Research and Therapy (2023)
40. Complications of Covid-19 Vaccines During Pregnancy; a Systematic Review, Archives of Academic Emergency Medicine (2022)
41. Breakthrough Sars-Cov-2 Infections After Vaccination: A Critical Review, Human Vaccines and Immunotherapeutics (2022)
42. Feasibility and Effectiveness of Vaccines for Covid-19: An Umbrella Review, Archives of Academic Emergency Medicine (2025)
43. Aging & Covid-19 Susceptibility, Disease Severity, and Clinical Outcomes: The Role of Entangled Risk Factors, Experimental Gerontology (2021)
44. Safety and Immunogenicity of Corenapcin, a Sars-Cov-2 Mrna Vaccine, As a Fourth Heterologous Booster in Healthy Iranian Adults: A Double-Blind, Randomized, Placebo-Controlled, Phase 1 Clinical Trial With a Six-Month Follow-Up, International Immunopharmacology (2024)
45. Immunogenicity of Covid-19 Mrna Vaccines in Immunocompromised Patients: A Systematic Review and Meta-Analysis, European Journal of Medical Research (2022)
46. Immunologic Response, Efficacy, and Safety of Vaccines Against Covid-19 Infection in Healthy and Immunosuppressed Children and Adolescents Aged 2 – 21 Years Old: A Systematic Review and Meta-Analysis, Journal of Clinical Virology (2022)
47. Safety and Efficacy of Imatinib, Nilotinib, and Artesunate in Covid-19 Patients: A Systematic Review of Current Evidence, Anti-Infective Agents (2024)
48. Minimum Infective Dose of Severe Acute Respiratory Syndrome Coronavirus 2 Based on the Current Evidence: A Systematic Review, SAGE Open Medicine (2022)
49. Evaluation of Seroconversion Rate Following Sars Cov 2 Vaccination in Health Care Workers at Shahid Beheshti University of Medical Sciences, Avicenna Journal of Medical Biotechnology (2023)
50. Comparison of Sars-Cov-2 (Coronavirus) With Other Similar Viruses Based on Current Evidence, Journal of Iranian Medical Council (2022)