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Covid-19 Vaccinations: The Unknowns, Challenges, and Hopes Publisher Pubmed



Mohamed K1, 2 ; Rzymski P3, 4 ; Islam MS5, 6 ; Makuku R1, 7 ; Mushtaq A8, 9 ; Khan A10, 11 ; Ivanovska M12, 13 ; Makka SA14, 15 ; Hashem F1, 2 ; Marquez L16, 17 ; Cseprekal O18, 19 ; Filgueiras IS20, 21 ; Fonseca DLM21, 22 ; Mickael E23, 24 Show All Authors
Authors
  1. Mohamed K1, 2
  2. Rzymski P3, 4
  3. Islam MS5, 6
  4. Makuku R1, 7
  5. Mushtaq A8, 9
  6. Khan A10, 11
  7. Ivanovska M12, 13
  8. Makka SA14, 15
  9. Hashem F1, 2
  10. Marquez L16, 17
  11. Cseprekal O18, 19
  12. Filgueiras IS20, 21
  13. Fonseca DLM21, 22
  14. Mickael E23, 24
  15. Ling I25, 26
  16. Arero AG1, 27
  17. Cuschieri S28, 29
  18. Minakova K30, 31
  19. Rodriguezroman E32, 33
  20. Abarikwu SO34, 35
  21. Faten AB36, 37
  22. Grancini G38, 39
  23. Cabralmarques O20, 21, 22
  24. Rezaei N1, 40, 41
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Universal Scientific Education and Research Network (USERN), Manama, Bahrain
  3. 3. Department of Environmental Medicine, Poznan University of Medical Sciences, Poznan, Poland
  4. 4. Universal Scientific Education and Research Network (USERN), Poznan, Poland
  5. 5. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Universal Scientific Education and Research Network (USERN), Dhaka, Bangladesh
  7. 7. Universal Scientific Education and Research Network (USERN), Harare, Zimbabwe
  8. 8. International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan
  9. 9. Universal Scientific Education and Research Network (USERN), Bishkek, Kyrgyzstan
  10. 10. Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan
  11. 11. Universal Scientific Education and Research Network (USERN), Islamabad, Pakistan
  12. 12. Department of Microbiology and Immunology, Research Center, Medical University, Plovdiv, Bulgaria
  13. 13. Universal Scientific Education and Research Network (USERN), Plovdiv, Bulgaria
  14. 14. Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
  15. 15. Universal Scientific Education and Research Network (USERN), Beirut, Lebanon
  16. 16. College of Social Sciences and Philosophy, University of the Philippines Diliman, Quezon City, Philippines
  17. 17. Universal Scientific Education and Research Network (USERN), Quezon City, Philippines
  18. 18. Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
  19. 19. Universal Scientific Education and Research Network (USERN), Budapest, Hungary
  20. 20. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  21. 21. Universal Scientific Education and Research Network (USERN), Sao Paulo, Brazil
  22. 22. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  23. 23. Department of Rheumatology and Physical Medicine, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
  24. 24. Universal Scientific Education and Research Network (USERN), Yaounde, Cameroon
  25. 25. School of Science, Monash University Malasia, Jalan Lagoon Selatan, Selangor, Darul Ehsan, Malaysia
  26. 26. Universal Scientific Education and Research Network (USERN), Selangor, Darul Ehsan, Malaysia
  27. 27. Universal Scientific Education and Research Network (USERN), Addis Ababa, Ethiopia
  28. 28. Faculty of Medicine and Surgery, University of Malta, Msida, Malta
  29. 29. Universal Scientific Education and Research Network (USERN), Valletta, Malta
  30. 30. National Technical University Kharkiv Polytechnic Institute, Kharkiv, Ukraine
  31. 31. Universal Scientific Education and Research Network (USERN), Kyiv, Ukraine
  32. 32. Center for Microbiology and Cell Biology, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
  33. 33. Universal Scientific Education and Research Network (USERN), Caracas, Venezuela
  34. 34. Department of Biochemistry, University of Port Harcourt, Choba, Nigeria
  35. 35. Universal Scientific Education and Research Network (USERN), Choba, Nigeria
  36. 36. Tunisia Polytechnic School, University of Carthage, Tunis, Tunisia
  37. 37. Universal Scientific Education and Research Network (USERN), Tunis, Tunisia
  38. 38. Department of Chemistry, Physical Chemistry Unit, University of Pavia, Pavia, Italy
  39. 39. Universal Scientific Education and Research Network (USERN), Pavia, Italy
  40. 40. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  41. 41. Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Journal of Medical Virology Published:2022


Abstract

The entire world has been suffering from the coronavirus disease 2019 (COVID-19) pandemic since March 11, 2020. More than a year later, the COVID-19 vaccination brought hope to control this viral pandemic. Here, we review the unknowns of the COVID-19 vaccination, such as its longevity, asymptomatic spread, long-term side effects, and its efficacy on immunocompromised patients. In addition, we discuss challenges associated with the COVID-19 vaccination, such as the global access and distribution of vaccine doses, adherence to hygiene guidelines after vaccination, the emergence of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, and vaccine resistance. Despite all these challenges and the fact that the end of the COVID-19 pandemic is still unclear, vaccines have brought great hope for the world, with several reports indicating a significant decline in the risk of COVID19-related infection and hospitalizations. © 2021 Wiley Periodicals LLC.
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