The Effect of Covid-19 Mrna Vaccines Against Postvaccination Laboratory-Confirmed Sars-Cov-2 Infection, Symptomatic Covid-19 Infection, Hospitalization, and Mortality Rate: A Systematic Review and Meta-Analysis Publisher Pubmed



Baradaran HR^{1, 2} ; Dehghanbanadaki H³ ; Moradpour F⁴ ; Eshrati B⁵ ; Moradi G⁴ ; Azami M⁶ ; Haji Ghadery A⁷ ; Mehrabi Nejad MM⁷ ; Moradi Y^{4, 8} Show Affiliations
Source: Expert Review of Vaccines Published:2022

Abstract

Objectives: We systematically reviewed the literature to investigate the pooled effect of COVID-19 mRNA vaccination against SARS-CoV-2 infection and its clinical outcomes. Methods: Scopus, Web of Science, PubMed (Medline), and Embase were searched on 9 September 2021. The odds ratio (OR) of COVID-19 infection and its clinical outcomes in fully/ partially vaccinated versus unvaccinated participants were calculated and pooled by using a random-effects model. Results: The pooled analysis showed that among health care workers and general population, vaccinated participants with one or two doses were less likely to infect with SARS-CoV-2 (OR = 0.16; 95%CI: 0.08–0.32; I2 = 79.86%; 95%CI I2: 68.99–87.21%), to develop symptomatic COVID-19 infection (OR = 0.09; 95%CI: 0.03–0.32; I2 = 80.43%; 95%CI I2: 70.83–89.33%), to admit to the hospital because of COVID-19 (OR = 0.13; 95%CI: 0.06–0.28; I2 = 86.19%; 95%CI I2: 67.80–93.88%), and to die from COVID-19 (OR = 0.14; 95%CI: 0.06–0.35; I2 = 66.76%; 95%CI I2: 54.00–76.99%) than unvaccinated participants. Conclusions: COVID-19 mRNA vaccines, especially following administration of two doses, are extremely effective. It would be suggested further studies with large sample size and different ethnicities to be conducted among the general population to warrant these results. © 2022 Informa UK Limited, trading as Taylor & Francis Group.