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Cd44 Epithelial Isoform Inversely Associates With Invasive Characteristics of Colorectal Cancer Publisher Pubmed



Sadeghi A1 ; Roudi R1 ; Mirzaei A2 ; Zare Mirzaei A3 ; Madjd Z1, 4 ; Abolhasani M1, 5
Authors
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Authors Affiliations
  1. 1. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran

Source: Biomarkers in Medicine Published:2019


Abstract

Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal cancer (CRC). Methodology: A total of 494 CRC samples (2008-2017) were assessed for CD44 (epithelial isoform) and CD24 expression using tissue microarray. Results: CD24 individually or in combination with CD44 was not associated with any of the clinicopathologic characteristics of the tumor. CD44 expression was inversely associated with pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) and lymphatic invasion (p = 0.05). Conclusion: In summary, the epithelial isoform of CD44 is inversely associated with invasive characteristics of CRC. © 2019 Future Medicine Ltd.
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