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Cancer Stem Cell Research in Iran: Potentials and Challenges Publisher Pubmed



Roudi R1 ; Ebrahimi M2 ; Shariftabrizi A3 ; Madjd Z1, 4
Authors
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Authors Affiliations
  1. 1. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Stem Cells and Developmental Biology at Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  3. 3. Department of Nuclear Medicine and Molecular Imaging, State University of New York at Buffalo, Buffalo, 14214, NY, United States
  4. 4. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Future Oncology Published:2017


Abstract

Treatment modalities can reduce cancer-related mortality; however, a majority of patients develop drug resistance, metastasis and relapse. It has been proposed that tumorigenic characteristics of tumors are related to a proportion of cancer cells, termed cancer stem cells (CSCs). Following the first evidence regarding the existence of CSC population in acute myeloid leukemia in 1997, publications in CSCs field showed an explosive trend in all cancer types around the world. First research paper in the field of CSCs in Iran was published in 2004 on prostate cancer. Subsequently, an annual number of publications in the field of CSCs displayed a rapidly growing trend. Therefore, in the current review, we have presented a comprehensive evaluation of the CSCs research in Iran. © 2017 2017 Future Medicine Ltd.
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