The Effect of Chromium Intake on Oxidative Stress Parameters: A Systematic Review and Meta-Analysis Publisher Pubmed



Morvaridzadeh M¹ ; Estevao MD² ; Qorbani M^{3, 4} ; Heydari H⁵ ; Hosseini AS⁶ ; Fazelian S⁷ ; Belancic A⁸ ; Persad E⁹ ; Rezamand G¹⁰ ; Heshmati J¹ Show Affiliations
Source: Journal of Trace Elements in Medicine and Biology Published:2022

Abstract

Background: Trivalent chromium is a trace element thought to have a beneficial effect on oxidative stress (OS) parameters and inflammation. This review aimed to investigate the dose-response of chromium and summarize the effects of chromium supplementation on OS parameters in the literature. Methods: MEDLINE, Scopus, Web of Science and Cochrane CENTRAL databases were searched for RCTs published from inception to January 2021 evaluating the effect of chromium supplementation on OS parameters, namely MDA, TBARS, SOD, TAS, CAT, GPx, and GSH. A random-effects model was used to pool data and calculated standard mean difference and 95 % confidence intervals. Quantified heterogeneity among studies was assessed through Cochrane's I2 values. Results: Nine studies enrolling 550 participants met the inclusion criteria. The obtained results indicate that chromium supplementation significantly increases TAC (SMD: 0.46; 95 % CI: 0.08, 0.84; I2 = 00.0 % n = 2) and significantly decreases MDA levels (SMD: −0.46; 95 % CI: −0.86, -0.07; I2 = 52.4 % n = 5). Supplementation did not significantly change CAT, GPx, GSH, SOD, TAS, and TBARS. Conclusion: Chromium supplementation may improve OS parameters, however, due to high heterogeneity observed in the included studies, these findings should be interpreted with caution. Large RCTs on various patient groups evaluating the impact of chromium supplementation are needed to allow an adequate generalization of the benefits of chromium on human health. © 2021 Elsevier GmbH