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Design and Implementation of Continuous Bed Motion (Cbm) in Xtrim Preclinical Pet Scanner for Whole-Body Imaging: Mc Simulation and Experimental Measurements Publisher Pubmed



Bahadorzadeh B1, 2 ; Faghihi R1, 3 ; Sina S1, 3 ; Aghaz A4 ; Rahmim A5, 6 ; Reza Ay M2, 7
Authors
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Authors Affiliations
  1. 1. Nuclear Engineering Department, School of Mechanical Engineering, Shiraz University, Shiraz, Iran
  2. 2. Research Center for Molecular and Cellular Imaging (RCMCI), Advanced Medical Technologies and Equipment Institute (AMTEI), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Radiation Research Center (RRC), Shiraz University, Shiraz, Iran
  4. 4. Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
  5. 5. Departments of Radiology and Physics Vancouver, The University of British Columbia, Vancouver, Canada
  6. 6. Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, Canada
  7. 7. Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Physica Medica Published:2024


Abstract

Purpose: Preclinical PET scanners often have limited axial field-of-view for whole-body (WB) scanning of the small-animal. Step-and-shoot(S&S) acquisition mode requires multiple bed positions (BPs) to cover the scan length. Alternatively, in Continuous Bed Motion(CBM) mode, data acquisition is performed while the bed is continuously moving. In this study, to reduce acquisition time and enhance image quality, the CBM acquisition protocol was optimized and implemented on the Xtrim-PET preclinical scanner for WB imaging. Methods: The over-scan percentage(OS%) in CBM mode was optimized by Monte Carlo simulation. Bed movement speed was optimized considering ranges from 0.1 to 2.0 mm s−1, and absolute system sensitivities with the optimal OS% were calculated. The performance of the scanner in CBM mode was measured, and compared with S&S mode based on the NEMA-NU4 standard. Results: The optimal trade-off between absolute sensitivity and uniformity of sensitivity profile was achieved at OS-50 %. In comparison to S&S mode with maximum ring differences (MRD) of 9 and 23, the calculated equivalent speeds in CBM(OS-50 %) mode were 0.3 and 0.14 mm s−1, respectively. In terms of data acquisition with equal sensitivity in both CBM(OS-50 %) and S&S(MRD-9) modes, the total scan time in CBM mode decreased by 25.9 %, 47.7 %, 54.7 %, and 58.2 % for scan lengths of 1 to 4 BPs, respectively. Conclusion: The CBM mode enhances WB PET scans for small-animals, offering rapid data acquisition, high system sensitivity, and uniform axial sensitivity, leading to improved image quality. Its efficiency and customizable scan length and bed speed make it a superior alternative. © 2024 Associazione Italiana di Fisica Medica e Sanitaria
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