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Phytostilbenes in Lymphoma: Focuses on the Mechanistic and Clinical Prospects of Resveratrol, Pterostilbene, Piceatannol, and Pinosylvin Publisher Pubmed



Goleij P1, 2, 3 ; Sanaye PM2, 3, 4 ; Babamohamadi M3, 5, 6 ; Tabari MAK7, 8 ; Amirian R3, 9, 10 ; Rezaee A11 ; Mirzaei H12 ; Kumar AP13, 14 ; Sethi G13, 14 ; Sadreddini S15 ; Jeandet P16 ; Khan H17
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Sana Institute of Higher Education, Sari, Iran
  2. 2. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  5. 5. Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran
  6. 6. Stem Cell and Regenerative Medicine Innovation Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. USERN Office, Mazandaran University of Medical Sciences, Sari, Iran
  9. 9. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  10. 10. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  11. 11. Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  12. 12. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  13. 13. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  14. 14. NUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  15. 15. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  16. 16. University of Reims Champagne-Ardenne, Research Unit “Induced Resistance and Plant Bioprotection�, RIBP-USC INRA 1488, Reims, 51100, France
  17. 17. Department of Pharmacy, Faculty of Chemical and Life Sciences, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan

Source: Leukemia Research Published:2024


Abstract

Lymphoma is a cancer affecting the lymphatic system that fights infections and diseases. In addition to surgery, radiotherapy, and chemotherapy, novel approaches have recently been investigated, such as phytostilbenes in treating lymphoma. Phytostilbenes are natural compounds present in various plants and have been shown to have different therapeutic effects, including anticancer properties. Resveratrol is a main phytostilbene with various derivates followed by pterostilbene and piceatannol. Studies have revealed that phytostilbenes can suppress the growth and proliferation of lymphoma cells by inducing apoptosis and inhibiting specific enzyme activity in cancer cell survival. The compounds also have antiinflammatory effects contributing to reducing lymphoma-associated inflammation. Additionally, phytostilbenes have been shown to increase the immune system's ability to fight cancer cells by activating immune cells (T-cells and natural killer cells). This review investigates the potential therapeutic effects of phytostilbenes, including resveratrol, pterostilbene, piceatannol, and pinosylvin, against lymphoma. © 2024 Elsevier Ltd
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