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Regulation of Long Non-Coding Rnas by Plant Secondary Metabolites: A Novel Anticancer Therapeutic Approach Publisher



Kalhori MR1 ; Khodayari H2, 3 ; Khodayari S2, 3 ; Vesovic M4 ; Jackson G5 ; Farzaei MH6 ; Bishayee A5
Authors
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Authors Affiliations
  1. 1. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 6714415185, Iran
  2. 2. International Center for Personalized Medicine, Dusseldorf, 40235, Germany
  3. 3. Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, 1419733141, Iran
  4. 4. Department of Mathematics, Statistics, and Computer Science, University of Illinois at Chicago, Chicago, 60607, IL, United States
  5. 5. Lake Erie College of Osteopathic Medicine, Bradenton, 34211, FL, United States
  6. 6. Medical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 6718874414, Iran

Source: Cancers Published:2021


Abstract

Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that play an essential role in various cellular activities, such as differentiation, proliferation, and apoptosis. Dysregulation of lncRNAs serves a fundamental role in the progression and initiation of various diseases, including cancer. Precision medicine is a suitable and optimal treatment method for cancer so that based on each patient’s genetic content, a specific treatment or drug is prescribed. The rapid advancement of science and technology in recent years has led to many successes in this particular treatment. Phytochemicals are a group of natural compounds extracted from fruits, vegetables, and plants. Through the downregulation of oncogenic lncRNAs or upregulation of tumor suppressor lncRNAs, these bioactive compounds can inhibit metastasis, proliferation, invasion, migration, and cancer cells. These natural products can be a novel and alternative strategy for cancer treatment and improve tumor cells’ sensitivity to standard adjuvant therapies. This review will discuss the antineo-plastic effects of bioactive plant secondary metabolites (phytochemicals) via regulation of expression of lncRNAs in various human cancers and their potential for the treatment and prevention of human cancers. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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