Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation

Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation Publisher Pubmed

Sanati M¹ ; Manavi MA² ; Noruzi M³ ; Behmadi H² ; Akbari T⁴ ; Jalali S² ; Sharifzadeh M² ; Khoobi M^{5, 6}

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1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. School of Pharmacy, Semnan University of Medical Sciences, Semnan, Iran
4. Department of Microbiology, Islamic Azad University, North Tehran Branch, Tehran, Iran
5. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Biomaterials Advances Published:2025

Abstract

Spinal cord injury (SCI) leaves a temporary or enduring motor, sensory, and autonomic function loss, significantly impacting the patient's quality of life. Given their biocompatibility, bioactivity, and tunable attributes, three-dimensional scaffolds frequently employ carbohydrates to facilitate spinal cord regeneration. These scaffolds have also been engineered to be novel local delivery platforms that present distinct advantages in the targeted transportation of drug candidates to the damaged spinal cord, ensuring the right dosage and duration of administration. Neurotrophic factors have emerged as promising therapeutic candidates, preserved neuron survival and encouraged severed axons repair, although their local and continuous delivery is believed to produce considerable spinal cord rehabilitation. This study aims to discuss breakthroughs in scaffold engineering, exploiting carbohydrates as an essential part of their structure, and highlight their impact on spinal cord regeneration and sustained neurotrophic factors delivery to treat SCI. © 2024 Elsevier B.V.

Style	Citing Format
MLA	Sanati M, et al.. "Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation." Biomaterials Advances, vol. 166, no. , 2025, pp. -.
APA	Sanati M, Manavi MA, Noruzi M, Behmadi H, Akbari T, Jalali S, Sharifzadeh M, Khoobi M (2025). Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation. Biomaterials Advances, 166(), -.
Chicago	Sanati M, Manavi MA, Noruzi M, Behmadi H, Akbari T, Jalali S, Sharifzadeh M, Khoobi M. "Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation." Biomaterials Advances 166, no. (2025): -.
Harvard	Sanati M et al. (2025) 'Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation', Biomaterials Advances, 166(), pp. -.
Vancouver	Sanati M, Manavi MA, Noruzi M, Behmadi H, Akbari T, Jalali S, et al.. Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation. Biomaterials Advances. 2025;166():-.
BibTex	@article{ author = {Sanati M and Manavi MA and Noruzi M and Behmadi H and Akbari T and Jalali S and Sharifzadeh M and Khoobi M}, title = {Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation}, journal = {Biomaterials Advances}, volume = {166}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Sanati M AU - Manavi MA AU - Noruzi M AU - Behmadi H AU - Akbari T AU - Jalali S AU - Sharifzadeh M AU - Khoobi M TI - Carbohydrates and Neurotrophic Factors: A Promising Partnership for Spinal Cord Injury Rehabilitation JO - Biomaterials Advances VL - 166 IS - SP - EP - PY - 2025 ER -

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