B Vitamins and Their Combination Could Reduce Migraine Headaches: A Randomized Double-Blind Controlled Trial Publisher



Nematgorgani S^{1, 2} ; Razeghijahromi S^{1, 2} ; Jafari E³ ; Togha M^{3, 4} ; Rafiee P³ ; Ghorbani Z^{5, 6} ; Ahmadi ZS⁷ ; Baigi V⁸ Show Affiliations
Source: Current Journal of Neurology Published:2022

Abstract

Background: The B vitamins can potentially help prevent migraine. This study was designed to examine the effects of supplementation with thiamine (B1), pyridoxine (B6), cobalamin (B12), folic acid (B9), and a combination of these vitamins on women with episodic migraine (EM). Methods: This study was a double-blind, placebo-controlled, randomized, clinical trial conducted on 120 women with EM. The participants were divided into the 6 groups of B1 (n = 20), B6 (n = 20), B12 (n = 20), B9 (n = 20), vitamin B complex (n = 20), and placebo (n = 20). Subjects received 1 capsule daily for 12 weeks. As part of the baseline and post-intervention phases, paper-based headache diaries were used to record the number of abortive drugs consumed and the frequency of headache attacks, and the Migraine Disability Assessment Questionnaire (MIDAS) was used to assess migraine disability. © 2022 Iranian Neurological Association, and Tehran University of Medical Sciences Published by Tehran University of Medical Sciences.