Unravelling the Treatment Strategies for Monkeypox Virus: Success and Bottlenecks Publisher Pubmed



P Yanadaiah PALAKURTHI ; Ak Gali Avinash KUMAR ; Rb Molakpogu Ravindra BABU ; S Vishwas SUKRITI ; Mv Chaitanya M VNL ; B Pal BIPLAB ; R Kumar RAKESH ; M Zandi MILAD ; G Gupta GAURAV ; Rj Macloughlin Ronan J
Source: Reviews in Medical Virology Published:2025

Abstract

Monkeypox virus (MPXV) is a zoonotic orthopoxvirus (ORXV) that causes a significant public health concern due to its potential for human-to-human transmission and ability to cause severe disease. Despite the availability of a vaccine, there is currently no specific antiviral treatment for MPXV. The development of effective therapeutic strategies for MPXV is essential to mitigate its harmful impact on society. Various strategies used to treat the MPXV infection include antiviral drugs, immunoglobulins, and supportive care measures. Antiviral drugs, such as cidofovir, brincidofovir, and tecovirimat, have shown promising results in in vitro and animal models, but their efficacy in human MPXV cases is still uncertain. This article provides a comprehensive review of the therapeutic strategies that have been explored for the management of MPXV virus infection. The review further highlights the challenges and limitations associated with the development and implementation of therapeutic strategies for MPXV. © 2025 Elsevier B.V., All rights reserved.