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Archives of Academic Emergency Medicine. Early General Hypothermia Improves Motor Function After Spinal Cord Injury in Rats; a Systematic Review and Meta-Analysis Publisher



Yousefifard M1 ; Vazirizadehmahabadi MH2 ; Haghani L3 ; Shokraneh F4 ; Vaccaro AR5 ; Rahimimovaghar V6, 7 ; Hosseini M8, 9
Authors
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Authors Affiliations
  1. 1. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, International Campus, Tehran University of Medical Science, Tehran, Iran
  4. 4. Cochrane Schizophrenia Group, Institute of Mental Health, University of Nottingham, Nottingham, United Kingdom
  5. 5. Department of Orthopedics and Neurosurgery, Rothman Institute, Thomas Jefferson University, Philadelphia, United States
  6. 6. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Brain and Spinal Injuries Research Center (BASIR), Neuroscience Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Academic Emergency Medicine Published:2020


Abstract

Introduction: There is still controversy about the effect of early hypothermia on the outcome of spinal cord injury (SCI). The aim of this review article is to investigate the effect of local or general hypothermia on improving the locomotion after traumatic SCI. Method: Electronic databases (Medline and Embase) were searched from inception until May 7, 2018. Two independent reviewers screened and summarized the relevant experimental studies on hypothermia efficacy in traumatic SCI. The data were analyzed and the findings were presented as pooled standardized mean difference (SMD) and 95% confidence interval (95% CI). Results: 20 papers contain-ing30separate experiments were includedinmeta-analysis. The onsetofhypothermia variedbetween0and 240 minutes after SCI. Administration of hypothermia has a positive effect on locomotion following SCI (SMD=0.56 95% CI: 0.18-0.95, p=0.004). Subgroup analysis showed that general hypothermia improves locomotion recovery (SMD =0.89, 95% CI: 0.42 to 1.36; p <0.0001), while local hypothermia does not have a significant effect on motor recovery (SMD=0.20, 95 % CI: -0.36-0.76, p=0.478). In addition, general hypothermia was found to affect motor recovery only if its duration was between 2 and 8 hours (SMD=0.89; p<0.0001) and the target temperature for induction of hypothermia was between 32 and 35°C C (SMD=0.83; p<0.0001). Conclusion: We found that general hypothermia improves locomotion after SCI in rats. Duration of induction and the target temperature are two essential considerations for general therapeutic hypothermia. © 2020, Archives of Academic Emergency Medicine. All Rights Reserved
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