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Application of Biosensors in Diagnosis of Human Parvoviruses Publisher



Hosseini F1, 2 ; Zandi M3 ; Behboudi E4 ; Salmanzadeh S5 ; Rasooli A6 ; Abbasi A3 ; Abbasi S7
Authors
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Authors Affiliations
  1. 1. Department of Applied Cell Sciences, School of Advanced Technologies on Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies on Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Infectious and Tropical Diseases Research Center, Health Research Institute, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Tehran, Ahvaz, Iran
  6. 6. Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran
  7. 7. Department of Microbiology, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran

Source: Journal of the Liaquat University of Medical and Health Sciences Published:2023


Abstract

Human parvovirus B19 is a viral pathogen that causes acute and usually self-limiting disease. Because the B19 virus predicates erythroid progenitor cells, it can cause a transient aplastic crisis in immunocompromised individuals. This infection has been associated with nonimmunologic fetal hydrops during pregnancy; also, B19 can persist for months in immunocompromised individuals. In B19 infection, viremia with a high titer is observed for approximately one week. After that, a specific immune response is critical to control the infection. Although molecular and serologic tests commonly diagnose the B19 virus, laboratory diagnostic tests have limitations. For the detection of human parvovirus B19, an inexpensive, effective, and rapid biosensor may be considered as an alternative. © 2023, Liaquat University of Medical and Health Sciences. All rights reserved.
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