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Preliminary Report of Iranian Registry of Alzheimer's Disease in Tehran Province: A Cross-Sectional Study in Iran Publisher



Fahanikbabaei J1, 2 ; Sedighi M1, 3 ; Mehrabi S1, 4 ; Pournik O1, 5 ; Sheikh Taheri A1, 6 ; Kamalzadeh L1, 7 ; Zarei M1, 8 ; Roghani M1, 9 ; Golab F1, 10 ; Almasi M1, 11 ; Etezadi A1, 12 ; Afshinmajd S1, 9 ; Malakouti SK1, 8 ; Rajabi M1, 13 Show All Authors
Authors
  1. Fahanikbabaei J1, 2
  2. Sedighi M1, 3
  3. Mehrabi S1, 4
  4. Pournik O1, 5
  5. Sheikh Taheri A1, 6
  6. Kamalzadeh L1, 7
  7. Zarei M1, 8
  8. Roghani M1, 9
  9. Golab F1, 10
  10. Almasi M1, 11
  11. Etezadi A1, 12
  12. Afshinmajd S1, 9
  13. Malakouti SK1, 8
  14. Rajabi M1, 13
  15. Moghaddasi M1, 11
  16. Hajati G1, 12
  17. Golmohammadi Khamne F1, 4
  18. Jafari A1, 4
  19. Amanollahi A1, 14
  20. Baluchnejadmojarad T1, 4
Show Affiliations
Authors Affiliations
  1. 1. Registry Program of Cognitive Deficit and Alzheimer's Disease Information in Tehran Province, Tehran, Iran
  2. 2. Electrophysiological Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Trauma and Injury Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran
  6. 6. School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. School of Behavioral Sciences and Mental Health, Tehran Psychiatric Institute, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Neurophysiology Research Center, Shahed University, Tehran, Iran
  10. 10. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  11. 11. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  12. 12. Iranian Dementia and Alzheimer's Association, Tehran, Iran
  13. 13. Department of Biology, Faculty of Science, Islamic Azad University of Shahr-E-Qods, Tehran, Iran
  14. 14. Department of Epidemiology, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Health Science Reports Published:2022


Abstract

Background and Aims: Alzheimer's disease (AD) is the main cause of dementia and over the 55 million people live with dementia worldwide. We aimed to establish the first database called the Iranian Alzheimer's Disease Registry to create a powerful source for future research in the country. In this report, the design and early results of the Iranian Alzheimer's Disease Registry will be described. Methods: We performed this multicenter investigation and patients' data including age, sex, educational level, disease status, Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS) from 2018 to 2021 were collected, registered, and analyzed by GraphPad Prism software. Results: Totally 200 AD patients were registered in our database. 107 (54%) were women and age of 147 (74%) were over 65. The mean age for men and women was 76.20 ± 8.29 and 76.40 ± 8.83 years, respectively. 132 (66%) were married and 64 (32%) were illiterate. Also, 94 (47%) were in the moderate stage of disease, and 150 (75%) lived at home together with their families. The most frequent neurological comorbidity was psychosis (n = 72, 36%), while hypertension was the most common non-neurological comorbidity (n = 104, 52%). The GDS score of women in the mild stage (5.23 ± 2.9 vs. 6.9 ± 2.6, p = 0.005) and moderate stage (5.36 ± 2.4 vs. 8.21 ± 2.06, p = <0.001) of the disease was significantly greater than men. In univariate analysis, MMSC score was remarkably associated with stroke (β = −2.25, p = 0.03), psychosis (β = −2.18, p = 0.009), diabetes (β = 3.6, p = <0.001), and hypercholesteremia (β = 1.67, p = 0.05). Also, the MMSE score showed a notable relationship with stroke (β = −2.13, p = 0.05) and diabetes (β = 3.26, p = <0.001) in multivariate analysis. Conclusion: Iranian Alzheimer's Disease Registry can provide epidemiological and clinical data to use for purposes such as enhancing the current AD management in clinical centers, filling the gaps in preventative care, and establishing effective monitoring and cure for the disease. © 2022 The Authors. Health Science Reports published by Wiley Periodicals LLC.
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