Tumor-Infiltrating Cd8+ Lymphocytes Effect on Clinical Outcome of Muco-Cutaneous Melanoma Publisher



Rahbar M¹ ; Naraghi ZS² ; Mardanpour M³ ; Mardanpour N⁴ Show Affiliations
Source: Indian Journal of Dermatology Published:2015

Abstract

Background: Recent data have changed our views of prognostic factors in cutaneous melanoma, while some newer methods have yielded better prognostic information. Tumor-infiltrating lymphocytes are believed to represent the immune reaction/response to melanoma cells which is often found in melanocytic cancer. Aim and Objective: We carried out an analysis, aiming to establish pooled estimates for clinical outcomes based on the presence of CD8+ T cell in melanocytic cancer. Materials and Methods: We have included 42 patients with primary cutaneous melanocytic cancer without preoperative treatments in our study. We next analyzed the proliferative activity of CD8+ T cells that infiltrated in tumor cell nests. The intratumoral and adjacent to invasive margin of tumor CD+ T-cell infiltration were analyzed which could also reflect antitumor immunity. Results: The total number of CD8+ cells especially adjacent to invasive margin of tumor was positively correlated with anatomical tumor thickness (P <.001) and not correlated with patient's age and sex. The stage of tumor which is related to vascular-neural invasion, regional lymph nodes involvement and tumor thickness shows positive correlation with CD8+ infiltration in tumor (P <.004, P <.005, P <.001), respectively. Acral melanoma shows more CD8 lymphocytes infiltration and also recurrence rate of tumor (P <.005). Conclusion: We believe that CD8+ T-cell infiltration in primary cutaneous melanocytic cancer represents the immune reaction/response to melanoma which could be an important new therapy for melanoma although more research is needed on this treatment modality. © 2015, Medical Knowledge. All rights reserved.