Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Determination of Phthalates in Bottled Milk by a Modified Nano Adsorbent: Presence, Effects of Fat and Storage Time, and Implications for Human Health Publisher



Dobaradaran S1, 2, 3, 4 ; Akhbarizadeh R1, 3 ; Javad Mohammadi M5 ; Izadi A2 ; Keshtkar M1, 2 ; Tangestani M2 ; Moazzen M6 ; Shariatifar N6, 7 ; Mahmoodi M8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Systems Environmental Health and Energy Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
  2. 2. Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
  3. 3. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
  4. 4. Instrumental Analytical Chemistry and Centre for Water and Environmental Research (ZWU), Faculty of Chemistry, University of Duisburg-Essen, Universitatsstr. 5, Essen, Germany
  5. 5. Department of Environmental Health Engineering, School of Public Health and Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Halal Research Center of IRI. FDA. MOH Tehran, Iran
  8. 8. Department of Biostatistics and Epidemiology, Bushehr University of Medical Sciences, Bushehr, Iran

Source: Microchemical Journal Published:2020


Abstract

Phthalate acid esters (PAEs) have attracted increasing attention because of their toxicity and ubiquity. In the present study, the level of five common PAEs in plastic bottled milk were determined using a novel adsorbent (a combination of multi-walled carbon nanotubes and iron oxide (Fe3O4) nanoparticles), and the PAEs’ associated potential risks to human were also assessed. The investigated compounds were dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (D-nOP). The good repeatability, high sensitivity, and short time extraction made this method an effective one for analysis of PAEs in milk. Twenty-four plastic bottled milk samples from 11 commercial brands were chosen according to their fat content and analyzed for target PAEs under different storage times (1 and four days upon purchased). The results revealed that the mean levels of PAEs were as follows: DnOP > DEHP > DBP > DEP > DMP. The results of correlation analysis and principal component (PC) biplot analysis revealed that DnOP and DEHP in the analyzed milk samples had common sources and/or similar chemical behavior. Moreover, fat content had a significant effect on the PAEs level of milk. While no significant correlation was obtained between the level of PAEs and the storage time. The estimated daily intake (EDI) of PAEs from bottled milk consumption were below the tolerable daily intake (TDI) values. Hence, daily consumption of bottled milk should not pose non-carcinogenic adverse health effects to humans. Moreover, the estradiol risk of bottled milk was low. © 2020 Elsevier B.V.
Related Docs
View other Related Docs
1. Analysis of Phthalate Acid Esters in Butter and Cheese Samples Using Mspe-Gc/Ms Method: A Health Risk Assessment Study, International Journal of Dairy Technology (2023)
2. Determination of Phthalate Acid Esters (Paes) in Carbonated Soft Drinks With Mspe/Gc–Ms Method, Toxin Reviews (2018)
3. Extraction and Measurement of Phthalate Acid Esters in Milk Using Carbon Nanotube Magnetized With Iron Oxide and Through Gc-Ms Device; [استخراج و اندازه گیری استرهای فتاالت در شیر با استفاده از نانوتیوب کربنی مغناطیسی شده باgc-Msاکسید آهن و از طریق دستگاه], Iranian Journal of Health and Environment (2023)
4. Evaluation of Phthalate Acid Esters (Paes) in Kefir Samples by Using Magnetic Chitosan Coated With Polyaniline (Fe3o4@Chi@Pani)/Gc–Ms Method: A Health Risk Assessment Study, Microchemical Journal (2024)
5. Endocrine Disruptor Phthalates in Bottled Water: Daily Exposure and Health Risk Assessment in Pregnant and Lactating Women, Environmental Monitoring and Assessment (2016)
6. Determination of Phthalic Acid Esters (Paes) Along With Probabilistic Health Risk Assessment in Fruit Juice Samples in Tehran, Iran, Environmental Science and Pollution Research (2023)
7. Investigation of Paes in Some Dairy Products (Yogurt and Kashk) Using Method of Mspe-Gc/Ms: A Health Risk Assessment Study, Environmental Science and Pollution Research (2024)
8. Method Development for Determination of Migrated Phthalate Acid Esters From Polyethylene Terephthalate (Pet) Packaging Into Traditional Iranian Drinking Beverage (Doogh) Samples: A Novel Approach of Mspe-Gc/Ms Technique, Environmental Science and Pollution Research (2018)
Experts (# of related papers)
View all Related Experts
Nabi Shariatifar (18)
Noushin Rastkari (6)
Other Related Docs
9. Extraction and Determination of Phthalate Esters (Paes) in Doogh, Journal of Mazandaran University of Medical Sciences (2017)
10. Concentrations of Phthalates in Bottled Water Under Common Storage Conditions: Do They Pose a Health Risk to Children?, Food Research International (2015)
11. Migration of Phthalate Compounds From Polyethylene Terephthalate Bottles Under Different Temperature Conditions- Probabilistic Human Health Risk Assessment, Journal of Food Science and Technology (2025)
12. A Margin of Exposure Approach to Assessment of Non-Cancerous Risk of Diethyl Phthalate Based on Human Exposure From Bottled Water Consumption, Environmental Science and Pollution Research (2015)
13. Bisphenol a Concentration in Canned Fruits and Vegetables and Their Risk Assessment Using Monte Carlo Simulation in Iran, Scientific Reports (2024)
14. The Effect of Storage Time, Temperature and Type of Packaging on the Release of Phthalate Esters Into Packed Acidic Liquids, Food Technology and Biotechnology (2017)
15. Assessing the Effect of Sunlight Exposure and Reuse of Polyethylene Terephthalate Bottles on Phthalate Migration, Science of the Total Environment (2025)
16. Measurement of Phthalate Acid Esters in Non-Alcoholic Malt Beverages by Mspe-Gc/Ms Method in Tehran City: Chemometrics, Environmental Science and Pollution Research (2021)
17. Investigating the Presence of Polycyclic Aromatic Hydrocarbons in Doogh, Journal of Mazandaran University of Medical Sciences (2019)
18. Measurement of Polycyclic Aromatic Hydrocarbons in Baby Food Samples in Tehran, Iran With Magnetic-Solid-Phase-Extraction and Gas-Chromatography/Mass-Spectrometry Method: A Health Risk Assessment, Frontiers in Nutrition (2022)
19. Thermo-Assisted Deep Eutectic Solvent Based on Dispersive Liquid-Liquid Microextraction for Preconcentration of Phthalate Esters in Water Samples and Determination by Gas Chromatography With Flame Ionization Detection, Journal of Separation Science (2024)
20. Magnetic Solid-Phase Extraction Based on Modified Magnetic Nanoparticles for the Determination of Phthalate Diesters in Water Samples, Journal of Chromatographic Science (2015)
21. Levels of Polycyclic Aromatic Hydrocarbons in Milk and Milk Powder Samples and Their Likely Risk Assessment in Iranian Population, Journal of Food Composition and Analysis (2020)
22. The Analysis and Probabilistic Health Risk Assessment of Pahs in Vegetables and Fruits Samples Marketed Tehran Chemometric, Global Nest Journal (2021)
23. Monitoring of Polycyclic Aromatic Hydrocarbons and Probabilistic Health Risk Assessment in Yogurt and Butter in Iran, Food Science and Nutrition (2021)
24. Study of the Antimicrobial Effects of Aqueous Extract of Olea Europaea, Solanum Nigrum, Artemisia Sieberi, Teucrium Polium, Glycyrrhiza Glabra on Some Food-Borne Pathogenic Bacteria, Journal of Medicinal Plants (2019)
25. The Analysis and Probabilistic Health Risk Assessment of Polycyclic Aromatic Hydrocarbons in Cereal Products, Environmental Science and Pollution Research (2022)
26. Measurement of Polycyclic Aromatic Hydrocarbons (Pahs) in Edible Mushrooms (Raw, Grilled and Fried) Using Mspe-Gc/Ms Method: A Risk Assessment Study, Applied Biological Chemistry (2021)