Association Between Resting Energy Expenditure, Diet and Uncoupling Protein 2 in Obese Women With Normal and Low Resting Energy Expenditure Publisher



Masoumi ZT¹ ; Eshraghian MR² ; Hosseini S³ ; Pishva H¹ Show Affiliations
Source: Nutrire Published:2023

Abstract

Purpose: Obesity is associated with increased risk for several metabolic diseases. Low Resting Energy Expenditure (REE) is considered a risk factor for weight gain and obesity. It was shown that diet composition can influence energy balance. Uncoupling Protein2 (UCP2) is a transporter protein presented in mitochondrial inner membrane which plays a role in cellular energy hemostasis. Our study was carried out to investigate the association between REE, diet and UCP2 in women with obesity in different REE. Methods: A total forty nine subjects participated in the current study. Sixteen subjects with body mass index (BMI) > 30 and low REE, seventeen subjects with BMI > 30 and normal REE, and Sixteen non-obese subjects as control group. Subjects with measured REE less than 20% of their predicted REE were defined as low REE. Anthropometric, body composition parameters and REE were measured. Fasting blood UCP2 in Peripheral blood mononuclear cell (PBMC) and thyroid hormones were determined. Validated questionnaires for 24-h food records was used. Results: There was a significant association between REE and protein intake in normal weight group (p-value = 0.03). In addition, there was a significant relationship between UCP2, protein and carbohydrate intake in group with obesity and low REE (p-value = 0.01, p-value < 0.01). After adjustment for age, fat-free mass and waist circumference, UCP2 was associated with measured REE in control group when compared to each group separately (95% CI, β = 0.42, p-value = 0.04). Furthermore there was a significant relationship between UCP2 and REE in three groups when we pooled (95% CI, β = 0.23, p-value = 0.04). Moreover, after adjustment for fat-free mass, we found, 0.15 decrease in the chance of low REE with the high level concentration of UCP2 in women with obesity (OR = 0.15, p-value = 0.04). Conclusion: There was an association between REE, UCP2 and dietary intake (protein and carbohydrate). In addition REE was lower in some women with obesity and decreasing in the level of UCP2 protein may relate to this problem. © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.