Comparison of the Effects of Dexamethasone Administration on Postoperative Sequelae Before and After “Third Molar” Extraction Surgeries Publisher Pubmed



Shoohanizad E¹ ; Parvin M¹
Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2020

Abstract

Introduction: Extraction of impacted third molars (ITMs) is one of the most common procedures in the field of oral and maxillofacial surgery in clinical practice. Administration of corticosteroid such as dexamethasone diminishes the postoperative sequelae. This study compared the effects of pre-operative and post-operative administration of dexamethasone on postoperative complications following third molar surgery. Methods: Data of all controlled clinical trials between 2006-2019 on the effects of pre-operative or post-operative dexamethasone administration on third-molar surgery sequelae were collected by searching the keywords: dexamethasone, third molar surgery, wisdom teeth, corticosteroids, oral surgery, maxillofacial surgery, preoperative, postoperative, pain, swelling, and trismus in international databases such as: Web of Science (ISI), PubMed, Scopus, Embase and Cochrane Library. Results: Twenty-six articles were included in this narrative review. Among them, 25 studies used dexamethasone in particular and 1 study used dexamethasone with amoxicillin. Twenty studies evaluated the effect of preoperative/postoperative dexamethasone administration on swelling, pain and trismus after third molar surgery. Six studies administered dexamethasone postoperatively and 14 studies administered the drug preoperatively. Four studies evaluated the preoperative and postoperative administration method. Sixteen studies used a 4 mg dexamethasone dose and drug administration was variable. The treatment period in postoperative studies varied between 1 to 7 days. Conclusion: Dexamethasone appears to be a promising agent in the reduction of postoperative sequelae in third molar surgery. As a potent anti-inflammatory agent, it has an effective role in pain, trismus and edema reduction distinguished from the routes of administration, dosage and timing, pre or postoperative prescription. © 2020 Bentham Science Publishers.