Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study

Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study Publisher Pubmed

Hosseinzadeh M¹ ; Ahmadpoor P² ; Yekaninejad MS³ ; Pourrezagholi F² ; Foroughi F⁴ ; Ghorbanpour M³ ; Barabadi M⁵ ; Shahbaz SK⁵ ; Solgi G⁶ ; Amirzargar A^{5, 7}

Show Affiliations

1. Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2. Department of Nephrology, Shahid Labbafinejad Medical Center, Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Immunology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
7. Molecular immunology research center, Tehran university of medical sciences, Tehran, Iran

Source: Transplant Immunology Published:2018

Abstract

This cohort intends to determine the sequential dynamic changes in Toll-like receptor (TLR)-4, TLR-2, and myeloid differentiation primary response gene 88 (MYD88) mRNA expressions in PBMCs and biopsy samples from kidney allograft recipients in relation to graft function. This study enrolled 52 renal transplant patients, 27 with well functioning graft (WFG) and 25 graft dysfunction (GD). Peripheral blood samples pre- and post-transplantation (days 2, 90 and 180) were collected to analyze mRNA expression levels of TLR-2, TLR-4, and MYD88 genes in relation to allograft function during one-year follow up. The mean dynamic changes of post-transplant TLR-2, TLR-4, and MYD88 mRNA expressions were significantly higher in GD compared to WFG patients (P =.001). ROC curve analysis based on glomerular filtration rate (GFR) index showed the area under curve (AUC) values for the genes: TLR-2(0.89;P <.001), TLR-4(0.86;P <.001), and MYD88(0.75;P =.003) in the third month post-transplantation for GD diagnosis. The calculated AUCs for the expressions of genes in allograft biopsies were 0.94(TLR-2), 0.95(TLR-4), and 0.98(MYD88) in the sixth month post-transplant based on pathology report (P <.001). Our results indicate that sequential monitoring of the expression patterns of TLR-2, TLR-4, and MYD88 in PBMCs and biopsy samples could be considered as predictive biomarkers for early and late kidney allograft function. © 2018

2. Tlr-2, Tlr-4 and Myd88 Genes Expression in Renal Transplant Acute and Chronic Rejections, International Journal of Immunogenetics (2019)

3. Toll-Like Receptor 4 in Renal Transplant, Experimental and Clinical Transplantation (2018)

4. Association Between Tlr2, Tlr4, and Cd14 Gene Polymorphisms and Acute Rejection in Kidney Transplant, Experimental and Clinical Transplantation (2018)

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Ali Akbar Amirzargar (4)

Mohammad Hossein Nicknam (2)

Style	Citing Format
MLA	Hosseinzadeh M, et al.. "Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study." Transplant Immunology, vol. 48, no. , 2018, pp. 26-31.
APA	Hosseinzadeh M, Ahmadpoor P, Yekaninejad MS, Pourrezagholi F, Foroughi F, Ghorbanpour M, Barabadi M, Shahbaz SK, Solgi G, Amirzargar A (2018). Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study. Transplant Immunology, 48(), 26-31.
Chicago	Hosseinzadeh M, Ahmadpoor P, Yekaninejad MS, Pourrezagholi F, Foroughi F, Ghorbanpour M, Barabadi M, Shahbaz SK, Solgi G, Amirzargar A. "Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study." Transplant Immunology 48, no. (2018): 26-31.
Harvard	Hosseinzadeh M et al. (2018) 'Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study', Transplant Immunology, 48(), pp. 26-31.
Vancouver	Hosseinzadeh M, Ahmadpoor P, Yekaninejad MS, Pourrezagholi F, Foroughi F, Ghorbanpour M, et al.. Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study. Transplant Immunology. 2018;48():26-31.
BibTex	@article{ author = {Hosseinzadeh M and Ahmadpoor P and Yekaninejad MS and Pourrezagholi F and Foroughi F and Ghorbanpour M and Barabadi M and Shahbaz SK and Solgi G and Amirzargar A}, title = {Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study}, journal = {Transplant Immunology}, volume = {48}, number = {}, pages = {26-31}, year = {2018} }
RIS	TY - JOUR AU - Hosseinzadeh M AU - Ahmadpoor P AU - Yekaninejad MS AU - Pourrezagholi F AU - Foroughi F AU - Ghorbanpour M AU - Barabadi M AU - Shahbaz SK AU - Solgi G AU - Amirzargar A TI - Expression Patterns of Toll Like Receptor (Tlr)-2, Tlr-4 and Myeloid Differentiation Primary Response Gene 88 (Myd88) in Renal Transplant Patients Developing Allograft Dysfunction; a Cohort Study JO - Transplant Immunology VL - 48 IS - SP - 26 EP - 31 PY - 2018 ER -

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