Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic Model, and Deep Learning Techniques: Are Retinal and Brain Neurodegenerative Disorders Related? Publisher



Latifinavid H1, 2 ; Barzegar Behrooz A3, 4 ; Jamehdor S5 ; Davari M1 ; Latifinavid M6 ; Zolfaghari N1 ; Piroozmand S1 ; Taghizadeh S1, 7 ; Bourbour M8 ; Shemshaki G9 ; Latifinavid S10 ; Arab SS11 ; Soheili ZS1 ; Ahmadieh H12 Show All Authors
Authors
  1. Latifinavid H1, 2
  2. Barzegar Behrooz A3, 4
  3. Jamehdor S5
  4. Davari M1
  5. Latifinavid M6
  6. Zolfaghari N1
  7. Piroozmand S1
  8. Taghizadeh S1, 7
  9. Bourbour M8
  10. Shemshaki G9
  11. Latifinavid S10
  12. Arab SS11
  13. Soheili ZS1
  14. Ahmadieh H12
  15. Sheibani N2
Show Affiliations
Authors Affiliations
  1. 1. Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, 1497716316, Iran
  2. 2. Departments of Ophthalmology and Visual Sciences and Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, 53705, WI, United States
  3. 3. Department of Human Anatomy and Cell Science, University of Manitoba College of Medicine, Winnipeg, R3T 2N2, MB, Canada
  4. 4. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, 1416634793, Iran
  5. 5. Department of Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, 6517838636, Iran
  6. 6. Department of Mechatronic Engineering, University of Turkish Aeronautical Association, Ankara, 06790, Turkey
  7. 7. Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, N6A 5C1, ON, Canada
  8. 8. Department of Biotechnology, Alzahra University, Tehran, 1993893973, Iran
  9. 9. Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysore, 570005, India
  10. 10. Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, 5619911367, Iran
  11. 11. Biophysics Department, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 1411713116, Iran
  12. 12. Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, 1666673111, Iran

Source: Pharmaceuticals Published:2023


Abstract

Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible visual impairment in the elderly. The current management of nAMD is limited and involves regular intravitreal administration of anti-vascular endothelial growth factor (anti-VEGF). However, the effectiveness of these treatments is limited by overlapping and compensatory pathways leading to unresponsiveness to anti-VEGF treatments in a significant portion of nAMD patients. Therefore, a system view of pathways involved in pathophysiology of nAMD will have significant clinical value. The aim of this study was to identify proteins, miRNAs, long non-coding RNAs (lncRNAs), various metabolites, and single-nucleotide polymorphisms (SNPs) with a significant role in the pathogenesis of nAMD. To accomplish this goal, we conducted a multi-layer network analysis, which identified 30 key genes, six miRNAs, and four lncRNAs. We also found three key metabolites that are common with AMD, Alzheimer’s disease (AD) and schizophrenia. Moreover, we identified nine key SNPs and their related genes that are common among AMD, AD, schizophrenia, multiple sclerosis (MS), and Parkinson’s disease (PD). Thus, our findings suggest that there exists a connection between nAMD and the aforementioned neurodegenerative disorders. In addition, our study also demonstrates the effectiveness of using artificial intelligence, specifically the LSTM network, a fuzzy logic model, and genetic algorithms, to identify important metabolites in complex metabolic pathways to open new avenues for the design and/or repurposing of drugs for nAMD treatment. © 2023 by the authors.
Related Docs
View other Related Docs
1. Age-Related Macular Degeneration and Neurodegenerative Disorders: Shared Pathways in Complex Interactions, Survey of Ophthalmology (2024)
2. Crosstalk Between Muc1 and Vegf in Angiogenesis and Metastasis: A Review Highlighting Roles of the Muc1 With an Emphasis on Metastatic and Angiogenic Signaling, Cancer Cell International (2021)
3. Crosstalk Between Mir-96 and Irs/Pi3k/Akt/ Vegf Cascade in Hrpe Cells; a Potential Target for Preventing Diabetic Retinopathy, PLoS ONE (2024)
4. Lipidomics-Driven Drug Discovery and Delivery Strategies in Glioblastoma, Biochimica et Biophysica Acta - Molecular Basis of Disease (2025)
5. The Circulating Ctrp13 in Type 2 Diabetes and Non-Alcoholic Fatty Liver Patients, PLoS ONE (2016)
6. Serum C1q/Tnf-Related Protein-2 (Ctrp2) Levels Are Associated With Coronary Artery Disease, Archives of Medical Research (2020)
7. Association of Arms2/Loc387715 A69s, Cfh Y402h, and Cfh I62v Polymorphisms With Retinal Angiomatous Proliferation Compared With Typical Age-Related Macular Degeneration: A Meta-Analysis, International Ophthalmology (2017)
8. Role of Complement Factor B Rs4151667 (L9h) Polymorphisms and Its Interactional Role With Cfh Y402h and C3 Rs2230199 (R102g) Risk Variants in Age-Related Macular Degeneration: A Case Control Study, BMC Ophthalmology (2020)
Experts (# of related papers)
View all Related Experts
Solaleh Emamgholipour (7)
Mehdi Yaseri (4)
Other Related Docs
9. Increased Mrna Expression of Ctrp3 and Ctrp9 in Adipose Tissue From Obese Women: Is It Linked to Obesity-Related Parameters and Mrna Expression of Inflammatory Cytokines?, Reports of Biochemistry and Molecular Biology (2020)
10. Endoplasmic Reticulum Stress As an Underlying Factor in Leading Causes of Blindness and Potential Therapeutic Effects of 4-Phenylbutyric Acid: From Bench to Bedside, Expert Review of Ophthalmology (2022)
11. The Circulating Levels of Complement-Clq/Tnf-Related Protein 13 (Ctrp13) in Patients With Type 2 Diabetes and Its Association With Insulin Resistance, Clinical Laboratory (2017)
12. Topological Analysis of Regulatory Networks Reveals Functionally Key Genes and Mirnas Involved in the Differentiation of Mesenchymal Stem Cells, Iranian Journal of Biotechnology (2021)
13. Identification of Key Genes and Convergent Pathways Disrupted in Autism Spectrum Disorder Via Comprehensive Bioinformatic Analysis, Informatics in Medicine Unlocked (2021)
14. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)
15. The Role of Nitric Oxide–Cgmp Pathway in Selegiline Antidepressant-Like Effect in the Mice Forced Swim Test, Pharmacological Reports (2018)
16. Neurobiology and Consequences of Social Isolation Stress in Animal Model—A Comprehensive Review, Biomedicine and Pharmacotherapy (2018)
17. Circulating Levels of C1q/Tnf-Α‐Related Protein 6 (Ctrp6) in Coronary Artery Disease and Its Correlation With Inflammatory Markers, Journal of Diabetes and Metabolic Disorders (2024)
18. Chloroquine-Induced Scratching Is Mediated by No/Cgmp Pathway in Mice, Pharmacology Biochemistry and Behavior (2015)
19. Association of C1q/Tnf-Related Protein-3 (Ctrp3) and Ctrp13 Serum Levels With Coronary Artery Disease in Subjects With and Without Type 2 Diabetes Mellitus, PLoS ONE (2016)
20. Rna Sequencing of Cd4+ T Cells in Relapsing–Remitting Multiple Sclerosis Patients at Relapse: Deciphering the Involvement of Novel Genes and Pathways, Journal of Molecular Neuroscience (2021)
21. Overexpression of Ddit4 and Tptep1 Are Associated With Metastasis and Advanced Stages in Colorectal Cancer Patients: A Study Utilizing Bioinformatics Prediction and Experimental Validation, Cancer Cell International (2021)
22. Retinal and Choroidal Changes After Anti-Vegf Therapy in Neovascular-Amd Patients: A Systematic Review and Meta-Analysis of Sd-Oct Studies, Survey of Ophthalmology (2024)
23. Circulating Ctrp5 in Rheumatoid Arthritis: An Exploratory Biomarker Study, BMC Rheumatology (2022)
24. Identification of Celecoxib-Targeted Proteins Using Label-Free Thermal Proteome Profiling on Rat Hippocampus, Molecular Pharmacology (2021)
25. Evaluation of Changing the Pattern of Ctrp5 and Inflammatory Markers Levels in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus, Archives of Physiology and Biochemistry (2022)
26. Joint Association of Complement Component 3 and Cc-Cytokine Ligand2 (Ccl2) or Complement Component 3 and Cfh Polymorphisms in Age-Related Macular Degeneration, Ophthalmic Genetics (2017)
27. Association of the Dna Repair Smug1 Rs3087404 Polymorphism and Its Interaction With High Sensitivity C-Reactive Protein for Age-Related Macular Degeneration in Iranian Patients, Ophthalmic Genetics (2017)
28. C1q/Tnf-Related Protein-1: Potential Biomarker for Early Diagnosis of Autism Spectrum Disorder, International Journal of Immunopathology and Pharmacology (2022)
29. Prediction of Novel Biomarkers for Gastric Intestinal Metaplasia and Gastric Adenocarcinoma Using Bioinformatics Analysis, Heliyon (2024)
30. Circulating Level of Ctrp1 in Patients With Nonalcoholic Fatty Liver Disease (Nafld): Is It Through Insulin Resistance?, PLoS ONE (2015)
31. Ctrp1 in Liver Disease, Advances in Clinical Chemistry (2017)
32. The Gene Expression of Ctrp12 But Not Ctrp13 Is Upregulated in Both Visceral and Subcutaneous Adipose Tissue of Obese Subjects, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
33. The C1q/Tnf-Related Proteins (Ctrps) in Pathogenesis of Obesity-Related Metabolic Disorders: Focus on Type 2 Diabetes and Cardiovascular Diseases, Life Sciences (2020)
34. The Association of Circulating Levels of Complement-C1q Tnf-Related Protein 5 (Ctrp5) With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes: A Case-Control Study, Diabetology and Metabolic Syndrome (2015)
35. Decreased Serum Levels of Ctrp12/Adipolin in Patients With Coronary Artery Disease in Relation to Inflammatory Cytokines and Insulin Resistance, Cytokine (2019)