Association of Arms2/Loc387715 A69s, Cfh Y402h, and Cfh I62v Polymorphisms With Retinal Angiomatous Proliferation Compared With Typical Age-Related Macular Degeneration: A Meta-Analysis Publisher Pubmed



Jabbarpoor Bonyadi MH¹ ; Yaseri M² ; Bonyadi M³ ; Soheilian M¹ Show Affiliations
Source: International Ophthalmology Published:2017

Abstract

Purpose: To compare the published results of studies on the genotype association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V in cases diagnosed as retinal angiomatous proliferation (RAP) versus neovascular age-related macular degeneration (AMD) or healthy controls. Methods: Heterogeneity of studies was evaluated using Cochran’s Q test and I-square index. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA. Results: Four studies were included with 1076 neovascular AMD patients, 222 RAP cases, and 2276 control subjects. Pooled overall odds ratios for RAP/AMD were 1.15 (95% CI 0.60–2.18) for GT versus GG, 3.52 (95% CI 1.25–9.91) for TT versus GG ARMS2, 0.98 (95% CI 0.22–4.29) for GA versus AA, 1.00 (95% CI 0.25–4.02) for GG versus AA CFHI62V, 0.57 (95% CI 0.35–0.93) for CT versus TT CFH Y402H, and 0.40 (95% CI 0.22–0.74) for CC versus TT CFH Y402H. Regression analysis showed that ARMS2 TT genotype has a statistically significant effect on RAP versus AMD compared to CFH genotypes (P < 0.001). Conclusion: This meta-analysis disclosed a stronger effect of ARMS2 genotypes in RAP cases compared with CFH Y402H and I62V genotypes. © 2016, Springer Science+Business Media Dordrecht.