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Iranome: A Catalog of Genomic Variations in the Iranian Population Publisher Pubmed



Fattahi Z1, 2 ; Beheshtian M1, 2 ; Mohseni M1, 2 ; Poustchi H3 ; Sellars E4 ; Nezhadi S5 ; Amini A6 ; Arzhangi S1 ; Jalalvand K1 ; Jamali P7 ; Mohammadi Z3 ; Davarnia B1 ; Nikuei P8 ; Oladnabi M1 Show All Authors
Authors
  1. Fattahi Z1, 2
  2. Beheshtian M1, 2
  3. Mohseni M1, 2
  4. Poustchi H3
  5. Sellars E4
  6. Nezhadi S5
  7. Amini A6
  8. Arzhangi S1
  9. Jalalvand K1
  10. Jamali P7
  11. Mohammadi Z3
  12. Davarnia B1
  13. Nikuei P8
  14. Oladnabi M1
  15. Mohammadzadeh A1
  16. Zohrehvand E1
  17. Nejatizadeh A8
  18. Shekari M8
  19. Bagherzadeh M4
  20. Shamsigooshki E9, 10
  21. Borno S11
  22. Timmermann B11
  23. Haghdoost A12, 13
  24. Najafipour R14
  25. Khorram Khorshid HR1
  26. Kahrizi K1
  27. Malekzadeh R3
  28. Akbari MR4, 15, 16
  29. Najmabadi H1, 2
Show Affiliations
Authors Affiliations
  1. 1. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  2. 2. Kariminejad–Najmabadi Pathology & Genetics Center, Tehran, Iran
  3. 3. Digestive Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Women's College Research Institute, University of Toronto, Toronto, ON, Canada
  5. 5. Department of Computer Science, University of Toronto, Toronto, ON, Canada
  6. 6. Information Technology Office, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  7. 7. Shahrood Genetic Counseling Center, Welfare Office, Semnan, Iran
  8. 8. Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  9. 9. Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Max Planck Institute for Molecular Genetics, Berlin, Germany
  12. 12. Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  13. 13. Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  14. 14. Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran
  15. 15. Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
  16. 16. Institute of Medical Science, University of Toronto, Toronto, ON, Canada

Source: Human Mutation Published:2019


Abstract

Considering the application of human genome variation databases in precision medicine, population-specific genome projects are continuously being developed. However, the Middle Eastern population is underrepresented in current databases. Accordingly, we established Iranome database (www.iranome.com) by performing whole exome sequencing on 800 individuals from eight major Iranian ethnic groups representing the second largest population of Middle East. We identified 1,575,702 variants of which 308,311 were novel (19.6%). Also, by presenting higher frequency for 37,384 novel or known rare variants, Iranome database can improve the power of molecular diagnosis. Moreover, attainable clinical information makes this database a good resource for classifying pathogenicity of rare variants. Principal components analysis indicated that, apart from Iranian-Baluchs, Iranian-Turkmen, and Iranian-Persian Gulf Islanders, who form their own clusters, rest of the population were genetically linked, forming a super-population. Furthermore, only 0.6% of novel variants showed counterparts in “Greater Middle East Variome Project”, emphasizing the value of Iranome at national level by releasing a comprehensive catalog of Iranian genomic variations and also filling another gap in the catalog of human genome variations at international level. We introduce Iranome as a resource which may also be applicable in other countries located in neighboring regions historically called Greater Iran (Persia). © 2019 Wiley Periodicals, Inc.
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