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Distinct Genetic Variation and Heterogeneity of the Iranian Population Publisher Pubmed



Mehrjoo Z1 ; Fattahi Z1 ; Beheshtian M1 ; Mohseni M1 ; Poustchi H2 ; Ardalani F1 ; Jalalvand K1 ; Arzhangi S1 ; Mohammadi Z2 ; Khoshbakht S1 ; Najafi F3 ; Nikuei P4 ; Haddadi M5 ; Zohrehvand E1 Show All Authors
Authors
  1. Mehrjoo Z1
  2. Fattahi Z1
  3. Beheshtian M1
  4. Mohseni M1
  5. Poustchi H2
  6. Ardalani F1
  7. Jalalvand K1
  8. Arzhangi S1
  9. Mohammadi Z2
  10. Khoshbakht S1
  11. Najafi F3
  12. Nikuei P4
  13. Haddadi M5
  14. Zohrehvand E1
  15. Oladnabi M6, 7
  16. Mohammadzadeh A1
  17. Jafari MH1
  18. Akhtarkhavari T1
  19. Gooshki ES8, 9
  20. Haghdoost A10, 11
  21. Najafipour R12
  22. Niestroj LM13
  23. Helwing B14
  24. Gossmann Y15
  25. Toliat MR13
  26. Malekzadeh R2, 15
  27. Nurnberg P13, 16
  28. Kahrizi K1
  29. Najmabadi H1
  30. Nothnagel M13, 16
Show Affiliations
Authors Affiliations
  1. 1. Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
  2. 2. Digestive Disease Research Centre, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  5. 5. Department of Biology, University of Zabol, Zabol, Iran
  6. 6. Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  7. 7. Department of Medical Genetics, Faculty of Advanced Medical Technologies, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  8. 8. Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  11. 11. Regional Knowledge Hub, WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
  12. 12. Cellular and Molecular Research Centre, Genetic Department, Qazvin University of Medical Sciences, Qazvin, Iran
  13. 13. Cologne Center for Genomics, University of Cologne, Cologne, Germany
  14. 14. Department of Archaeology, University of Sydney, Australia
  15. 15. Noncommunicable Disease Research Center, Shiraz University of Medical Science, Shiraz, Iran
  16. 16. University Hospital Cologne, Cologne, Germany

Source: PLoS Genetics Published:2019


Abstract

Iran, despite its size, geographic location and past cultural influence, has largely been a blind spot for human population genetic studies. With only sparse genetic information on the Iranian population available, we pursued its genome-wide and geographic characterization based on 1021 samples from eleven ethnic groups. We show that Iranians, while close to neighboring populations, present distinct genetic variation consistent with long-standing genetic continuity, harbor high heterogeneity and different levels of consanguinity, fall apart into a cluster of similar groups and several admixed ones and have experienced numerous language adoption events in the past. Our findings render Iran an important source for human genetic variation in Western and Central Asia, will guide adequate study sampling and assist the interpretation of putative disease-implicated genetic variation. Given Iran’s internal genetic heterogeneity, future studies will have to consider ethnic affiliations and possible admixture. © 2019 Mehrjoo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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