Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Platelet-Rich Plasma Gel Potential in Acceleration of Wound Healing Duration in Patients Underwent Pilonidal Sinus Surgery: A Randomized Controlled Parallel Clinical Trial Publisher Pubmed



Mohammadi S1 ; Nasiri S2 ; Mohammadi MH3 ; Malek Mohammadi A1 ; Nikbakht M1 ; Zahed Panah M5 ; Safar H4 ; Mostafaei S1 ; Norooznezhad AH1 ; Soroosh AR2 ; Alimoghaddam K1 ; Ghavamzadeh A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Surgery Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. BMT Ward, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Pathology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

Source: Transfusion and Apheresis Science Published:2017


Abstract

Objectives One of the most important surgical issues applied in the treatment of pilonidal sinus disease is wound healing. The aim of this study was to investigate the possible effect of platelet-rich plasma (PRP) gel on accelerating wound healing in these patients. Methods In this randomized, controlled, parallel group clinical trial, 110 patients were randomly allocated into two parallel groups with the same size (controls and treatment arm) after meeting inclusion and exclusion criteria. After the surgery, controls were treated by classic wound dressing while the case group was treated with PRP gel in a classic wound dressing platform. The patients were then evaluated for duration of antibiotics consumption, experienced pain and the time of returning to routine activities. Also, both groups were assessed for angiogenesis (by detecting CD34+ cells using immunohistochemical assay) and collagen sedimentation (masson's trichrome staining) using pre-complete healing wound biopsy. All the statistical analyses were performed using SPPS 20 and p-values of less than 0.05 considered statically significant. Results According to the results, patients treated with PRP gel went through a significantly faster healing process (8.69 ± 1.18 in controls and 4.78 ± 0.87 weeks in PRP gel treated ones with the P-value = 0.03) and returned to their routine activities (3.3 ± 0.64 for the treatment of arm and 6.5 ± 1.03 weeks for controls with the P-value = 0.00) while experiencing less pain (P-value = 0.00) and shorter anti-biotic consumption duration (P-value = 0.00). Conclusion Considering the results, authors of this study suggest PRP gel treatment for post operation wound dressing of pilonidal sinus disease with healing by secondary intention. © 2017 Elsevier Ltd
Related Docs
1. Effectiveness of Platelet-Rich Plasma Therapy in Wound Healing of Pilonidal Sinus Surgery: A Comprehensive Systematic Review and Meta-Analysis, Wound Repair and Regeneration (2017)
2. A Randomized Controlled Trial of Effectiveness of Platelet-Rich Plasma Gel and Regular Dressing on Wound Healing Time in Pilonidal Sinus Surgery: Role of Different Affecting Factors, Biomedical Journal (2019)
3. Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction After Pelvic Irradiation, Asian Pacific Journal of Cancer Prevention (2019)
4. Cannabinoids: Possible Agents for Treatment of Psoriasis Via Suppression of Angiogenesis and Inflammation, Medical Hypotheses (2017)
5. Evaluation of Wound Healing in Diabetic Foot Ulcer Using Platelet-Rich Plasma Gel: A Single-Arm Clinical Trial, Transfusion and Apheresis Science (2017)
Experts (# of related papers)
View all Related Experts
Saeed Mohammadi (4)
Mohsen Nikbakht (2)