Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice

Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice Publisher Pubmed

Khakpai F¹ ; Issazadeh Y² ; Rezaei N² ; Zarrindast MR^{2, 3, 4}

Show Affiliations

1. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Iran
2. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran
3. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Iran
4. Department of Neuroendocrinology, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: NeuroReport Published:2022

Abstract

The involvement of the opioidergic system on anxiolytic and antinociceptive responses induced by cholestasis was investigated in cholestatic and addicted mice. Elevated plus-maze and tail-flick devices were used to assess anxiety and pain levels, respectively. The data indicated that induction of cholestasis and injection of opioid drugs including morphine and tramadol enhanced %OAT and %OAE but naloxone reduced %OAT and %OAE in the sham-operated and bile duct ligation (BDL) mice. Induction of cholestasis and addiction to morphine and tramadol prolonged tail-flick latency, which was reversed by naloxone. Coadministration of morphine and tramadol enhanced anxiolytic and analgesic effects in the sham-operated and BDL mice. It seems (a) cholestasis and addiction affect anxiety and pain behaviors, (b) μ-opioid receptors play a key role in anxiolytic and analgesic effects induced by cholestasis, and (c) cotreatment with morphine and tramadol augmented the effectiveness of them for induction of anxiolytic and analgesic effects both in cholestatic and addicted mice. © 2022 Lippincott Williams and Wilkins. All rights reserved.

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Ahmad Reza Dehpour (4)

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Style	Citing Format
MLA	Khakpai F, et al.. "Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice." NeuroReport, vol. 33, no. 16, 2022, pp. 681-689.
APA	Khakpai F, Issazadeh Y, Rezaei N, Zarrindast MR (2022). Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice. NeuroReport, 33(16), 681-689.
Chicago	Khakpai F, Issazadeh Y, Rezaei N, Zarrindast MR. "Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice." NeuroReport 33, no. 16 (2022): 681-689.
Harvard	Khakpai F et al. (2022) 'Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice', NeuroReport, 33(16), pp. 681-689.
Vancouver	Khakpai F, Issazadeh Y, Rezaei N, Zarrindast MR. Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice. NeuroReport. 2022;33(16):681-689.
BibTex	@article{ author = {Khakpai F and Issazadeh Y and Rezaei N and Zarrindast MR}, title = {Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice}, journal = {NeuroReport}, volume = {33}, number = {16}, pages = {681-689}, year = {2022} }
RIS	TY - JOUR AU - Khakpai F AU - Issazadeh Y AU - Rezaei N AU - Zarrindast MR TI - Enhanced Anxiolytic and Analgesic Effectiveness or a Better Safety Profile of Morphine and Tramadol Combination in Cholestatic and Addicted Mice JO - NeuroReport VL - 33 IS - 16 SP - 681 EP - 689 PY - 2022 ER -

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